197371-49-6

Basic information

• Product Name: 3β-Hydroxy-des-D-13α-androstan-14-one
• CAS NO: 197371-49-6
• Molecular Weight: 250.381
• Mol File: 197371-49-6.mol

Chemical Properties

• CAS DataBase Reference: 3β-Hydroxy-des-D-13α-androstan-14-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-Hydroxy-des-D-13α-androstan-14-one(197371-49-6)
• EPA Substance Registry System: 3β-Hydroxy-des-D-13α-androstan-14-one(197371-49-6)

Safety Data

• Hazardous Substances Data: 197371-49-6(Hazardous Substances Data)

Relevant articles and documents

The Retro-Michael Reaction of 1,5-Dicarbonyl Compounds: Scope and Limitation

Under catalysis of NaOH or KOH adsorbed on glass wool and by using steam distillation, (20R,S)-4,4,5,14-tetramethyl-18,19-dinor-13,17-seco-5β,8α,9β,10α,14β-cholestane-13,17-dione (1) and 3,14-dioxo-14,15-seco-5α-cholestan-15-al (4) gave good yield (>59 percent) of the corresponding tricyclic compounds (8a, 8b and 10a) via a retro-Michael reaction at 250 deg C. While 5-oxo-4-nor-3,5-secocholestan-3-oic acid (6) and ethyl 5-oxo-4-nor-3,5-secocholestan-3-oate (7) afforded low yield (15 percent) of the retro-Michael cleavage products (12a, 12b) at the same conditions. Thus, the retro-Michael reaction worked well for 1,5-diketones and 1,5-keto aldehydes but gave poor yield for 1,5-keto esters and 1,5-keto acids.