197386-28-0Relevant academic research and scientific papers
A trifluoromethyl group directed semipinacol rearrangement: Synthesis of α-(trifluoroacetyl) diarylmethanes
Hornyak, Gyula,Fetter, J.ozsef,Nemeth, G.abor,Poszavacz,Simig, Gyula
, p. 49 - 51 (1997)
Semipinacol rearrangements of trifluoromethyl substituted vic-diol monomethyl ethers proceeded smoothly to give α-(trifluoroacetyl) diarylmethanes in good yields. The trifluoromethyl group gave specific orientation to the course of the rearrangement.
Preparation of α,α-disubstituted trifluoromethyl ketones via Suzuki reaction of bromoenamines
Legros, Julien,Bouvet, Denis,Crousse, Benoit,Bonnet-Delpon, Daniele,Begue, Jean-Pierre
, p. 838 - 842 (2000)
Palladium-catalyzed cross-coupling reaction of β-amino-β- trifluoromethylvinyl bromides 7 and 8 with boronic acids has been achieved to afford new stable β,β-disubstituted α-trifluoromethyl enamines 12 and 13, which can be used as masked ketones. The ketone function can be released in acidic medium.
