197387-11-4Relevant academic research and scientific papers
ENANTIOSELECTIVE DEPROTONATION OF TWO RACEMIC CYCLIC CARBONYL COMPOUNDS BY A CHIRAL LITHIUM AMIDE
Eleveld, M. B.,Hogeveen, H.
, p. 631 - 634 (1986)
The cyclic carbonyl compounds 2 and 8 have been obtained in optical active form (o.y. 46percent and 36percent, respectively) from the racemic compounds by a deprotonation/protonation sequence, using chiral lithium amide 1.The optical activity of 2 is caus
Concise synthesis and applications of enantiopure spirobiphenoxasilin-diol and its related chiral ligands
Liu, Tao,Wang, Biqin,Wang, Peng,Wu, Yichen,Xu, Wen-Qiang,Yang, Lei
supporting information, p. 13365 - 13368 (2021/12/17)
The development of chiral architectures for chiral ligand and catalyst discovery is essential for asymmetric catalysis. Herein, we report the concise synthesis of a Si-centered spirocyclic skeleton, spirobiphenoxasilin-diol (SPOSiOL), and its derived chiral ligands. Using the chemical resolution method, the optical SPOSiOL could be obtained in high yield on a gram scale. Preliminary studies indicated that this ligand scaffold has great potential in transition metal-catalyzed asymmetric reactions. This finding further highlights that the Si-centered spirocyclic scaffolds are of great value in asymmetric catalysis. This journal is
ENANTIOSELECTIVE ADDITION OF N-BUTYLLITHIUM TO BENZALDEHYDE IN THE PRESENCE OF CHIRAL LITHIUM AMIDES
Eleveld, M. B.,Hogeveen, H.
, p. 5187 - 5190 (2007/10/02)
The reaction of n-butyllithium with benzaldehyde in the presence of chiral lithium amides 1a-e gives 1-phenyl-1-pentanol with optical yields up to 90 percent.
