197387-33-0Relevant academic research and scientific papers
Photoinduced Oxidation of Secondary Alcohols Using 4-Benzoylpyridine as an Oxidant
Kamijo, Shin,Tao, Keisuke,Takao, Go,Tonoda, Hiroshi,Murafuji, Toshihiro
supporting information, p. 3326 - 3329 (2015/07/15)
Photoinduced oxidation of secondary alcohols to ketones was achieved by utilizing an equimolar amount of 4-benzoylpyridine as an oxidant. This transformation proceeds at ambient temperature and exhibits high compatibility with polar functionalities including benzoyl, silyl, and methoxymethyl alcohol protecting groups as well as tosyloxy, bromo, sulfonyl, carbamate, ester, and carboxylic acid units. The present oxidation is solely promoted by the action of organic molecules without the aid of metallic reagents. (Chemical Equation Presented).
Structure-activity relationship of an ozonide carboxylic acid (oz78) against fasciola hepatica
Zhao, Qingjie,Vargas, Mireille,Dong, Yuxiang,Zhou, Lin,Wang, Xiaofang,Sriraghavan, Kamaraj,Keiser, Jennifer,Vennerstrom, Jonathan L.
experimental part, p. 4223 - 4233 (2010/09/04)
In this paper, we describe the SAR of ozonide carboxylic acid OZ78 (1) as the first part of our search for a trematocidal synthetic peroxide drug development candidate. We found that relatively small structural changes to 1 resulted most commonly in loss of activity against Fasciola hepatica in vivo. A spiroadamantane substructure and acidic functional group (or ester prodrug) were required for activity. Of 26 new compounds administered at single 100 mg/kg oral doses to F. hepatica infected rats, 8 had statistically significant worm burden reductions, 7 were partially curative, and 1 (acylsulfonamide 6) was completely curative and comparable to 1 in flukicidal efficacy. This study also showed that the activity of 1 is peroxide-bond-dependent, suggesting that its flukicidal efficacy depends upon hemoglobin digestion in F. hepatica.
