19739-02-7

Basic information

• Product Name: 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one
• CAS NO: 19739-02-7
• Molecular Formula: C₁₅H₁₁ClO₂
• Molecular Weight: 258.6996
• Mol File: 19739-02-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 435.2°C at 760 mmHg
• Flash Point: 217°C
• Density: 1.292g/cm³
• Vapor Pressure: 3.49E-08mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one(19739-02-7)
• EPA Substance Registry System: 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one(19739-02-7)

Safety Data

• Hazardous Substances Data: 19739-02-7(Hazardous Substances Data)

Usage

General Description

1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one is a chemical compound with a molecular formula C15H11ClO2. It is a chalcone derivative, which is a type of organic compound that is commonly found in plants. 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one contains a 4-chlorophenyl group and a 2-hydroxyphenyl group attached to a prop-2-en-1-one backbone. It is known for its potential biological activities, including antimicrobial, antioxidant, and anti-inflammatory properties. 1-(4-chlorophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one has been studied for its potential use in pharmaceuticals and in the development of new materials. Additionally, it has been investigated for its potential role in treating various diseases and conditions.

Upstream product

• 108-95-2 phenol 
• 99-91-2 para-chloroacetophenone 
• 90-02-8 salicylaldehyde 

Downstream Products

• 1381807-46-0 2-(4-chlorophenyl)-3-tosyl-4,4a-dihydro-3H-chromeno[3,4-c]pyridin-5(10bH)-one 
• 1414854-05-9 3-(2-(4-chlorophenyl)-4H-chromen-4-yl)-1H-indole 
• 1414854-06-0 5-bromo-3-(2-(4-chlorophenyl)-4H-chromen-4-yl)-1H-indole 
• 1427466-65-6 8-(4-Chlorophenyl)-8,14-methanobenzo[7,8][1,3]dioxocin-[5,4-c]chromen-1(14H)-one 

Relevant articles and documents

Novel isoniazid-spirooxindole derivatives: design, synthesis, biological evaluation, in silico ADMET prediction and computational studies

In the present scenario, the Synthesis of new and desired antimycobacterial agent has an eternal demand to resist Mycobacterium tuberculosis (MTB). The design and identification of new molecules for the treatment of tuberculosis is an important task in organic as well as medicinal chemistry research. In the present study, we have reported the combination of the desired compound using two versatile and significant moieties, isoniazid and spirooxindole derivatives. A series of novel isoniazid-spirooxindole hybrid molecules (6a-6ao) were designed, synthesized, and well-characterized by various spectroscopic methods. We have evaluated for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) strain and MDR-TB. Among them, Compound 6ab was found to be the most effective compare to other compounds. ADMET-related descriptors were to be calculated of all the compounds to predict the pharmacokinetic properties for the selection of the effective and bioavailable compounds. In addition, molecular docking and molecular dynamics studies reveal that the binding modes of all the compounds in the active site of isoniazid-resistant enoyl-ACP(COA) reductase, which helped to establish a structural basis of inhibition of Mycobacterium tuberculosis.

Synthesis of Functionalized Chromene and Chroman Derivatives via Cesium Carbonate Promoted Formal [4 + 2] Annulation of 2′-Hydroxychalcones with Allenoates

A new strategy has been established for the synthesis of functionalized chromene and chroman derivatives via a Cs2CO3-catalyzed domino addition of 2′-hydroxychalcone derivatives with allenoates, which can serve as a general avenue for the construction of multireplaced chromene derivatives. Chemoselectivity of this synthesis was found to depend on substituents on substrates. Good to excellent yields were achieved under simple and mild conditions at room temperature.

Synthesis of several types of 2,8-dioxabicyclo[3.3.1]nonanes using amberlyst-15 as an efficient recyclable heterogeneous catalyst

A facile synthesis of 2,8-dioxabicyclo[3.3.1]nonane derivatives starting from simple molecules, such as 2-hydroxychalcones as one component and dimedone, 4-hydroxycoumarin, 2-hydroxynaphthoquinone, 2-naphthol or 1-naphthol, as the other has been achieved by use of amberlyst-15, a sulfonated polystyrene resin, as a recyclable heterogeneous catalyst. The methodology involves a domino sequence of Michael addition and two-stage cyclisation.