197442-80-1

Basic information

• Product Name: 2-nitro-4-(1,1-dimethylethoxycarbonylamino)phenol
• Synonyms: 2-nitro-4-(1,1-dimethylethoxycarbonylamino)phenol
• CAS NO: 197442-80-1
• Molecular Weight: 254.243
• Mol File: 197442-80-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-nitro-4-(1,1-dimethylethoxycarbonylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-nitro-4-(1,1-dimethylethoxycarbonylamino)phenol(197442-80-1)
• EPA Substance Registry System: 2-nitro-4-(1,1-dimethylethoxycarbonylamino)phenol(197442-80-1)

Safety Data

• Hazardous Substances Data: 197442-80-1(Hazardous Substances Data)

Upstream product

• 119-34-6 4-amino-2-nitrophenol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1452303-67-1 C₂₅H₃₃N₃O₁₁ 

Relevant articles and documents

Synthesis and bioevaluation of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acid/carbohydrazide derivatives as potent xanthine oxidase inhibitors

A series of 2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylic acids/carbohydrazides as analogues of febuxostat were synthesized and evaluated for their in vitro xanthine oxidase (XO) inhibitory activity. Among these compounds, the carboxylic acid derivatives 7a-h and 8a-h exhibited high potency in the submicromolar/nanomolar range. Steady-state kinetics experiment revealed that 7f was a mixed-type inhibitor of xanthine oxidase. In addition, a molecular docking study of 7f was performed to determine its binding mode at the active site of xanthine oxidase.