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197450-40-1

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197450-40-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 197450-40-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,4,5 and 0 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 197450-40:
(8*1)+(7*9)+(6*7)+(5*4)+(4*5)+(3*0)+(2*4)+(1*0)=161
161 % 10 = 1
So 197450-40-1 is a valid CAS Registry Number.

197450-40-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[2-methyl-4-(2-oxopyrrolidin-1-yl)phenyl]benzoic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:197450-40-1 SDS

197450-40-1Relevant articles and documents

Multikilogram-scale synthesis of a biphenyl carboxylic acid derivative using a Pd/C-mediated suzuki coupling approach

Ennis, David S.,McManus, Julie,Wood-Kaczmar, Wladyslaw,Richardson, John,Smith, Gillian E.,Carstairs, Alexis

, p. 248 - 252 (1999)

Reaction of 4-bromo-3-methylaniline with 4-chlorobutyryl chloride/TEA and subsequent treatment of the resulting secondary amide intermediate with KOt-Bu gives 1-(4-bromo-3methylphenyl)pyrrolidin-2-one in 65% yield. This procedure has been optimised (74-76% overall yield) and has been carried out on 41 molar scale. In a variation of this process, we have employed NaOH as the ring-closing base under phase-transfer conditions. NaOH is added to a mixture of 4-bromo-3-methylaniline, 4-chlorobutyryl chloride, and catalytic TBAC in THF/ H2O. A further 2 equiv of aqueous NaOH is added, and the mixture is heated at 40-45 °C, providing access to cyclised product in an improved 86% yield. 1-(4-Bromo-3-methylphenyl)pyrrolidin-2-one is subsequently coupled with 4-carboxyphenylboronic acid under standard Suzuki coupling conditions [Pd(PPh3)4, Na2CO3, DME/H2O] to give 2′-methyl-4′-(2-oxo-1-pyrrolidinyl)biphenyl-4-carboxylic acid in 64% yield, contaminated with 40-80 ppm of residual Pd. In a modification of this process, we have used Pd/C as the catalyst. Reaction in MeOH/ H2O gives an improved yield of the biphenylcarboxylic acid with residual Pd levels of a one-pot procedure, providing access to 2′-methyl-4′-(2-oxo-1-pyrrolidinyl)biphenyl-4-carboxylic acid in 82% overall yield from 4-bromo-3-methylaniline.

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