19747-90-1Relevant academic research and scientific papers
ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
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Page/Page column 49, (2009/10/30)
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
Direct phosphorylation of N-protected imidazoles and benzoimidazoles - A route to 1H-imidazol(benzoimidazol)-2-yl phosphonic and phosphinic acids and their derivatives
Komarov, Igor V.,Strizhak, Aleksandr V.,Kornilov, Mikhail Yu.,Kostyuk, Aleksandr N.,Tolmachev, Andrey A.
, p. 2355 - 2370 (2007/10/03)
Synthetic approaches to 1H-imidazol-2-yl and 1H-benzoimidazol-2-yl phosphinic and phosphonic acids and their derivatives are reported, based on phosphorylation of N-protected heterocylcles by PhPOCl2 or MePOCl2. Reaction of N-alkylbe
Phosporylation of 1,3-di(N-alkyl)azoles by phosphorus(V) acid chlorides - A route to potential haptens derived from phosphinic acids
Komarov,Kornilov,Turov,Gorichko,Popov,Tolmachev,Kirby
, p. 12417 - 12424 (2007/10/02)
Phosphorylation of N-alkylated imidazoles and benzimidazoles at C-2 by CH3POCl2, PhPOCl2, POCl3 in pyridine-triethylamine solution is described. The formed heteroaryl-substituted phosphinic or phosphonic acid chlorides were transformed without isolation into the corresponding phosphinic (phosphinic) acids, their salts or amides with moderate yields. This reaction opens a simple way to potential haptens derived from phosphinic acids. These haptens mimic tetrahedral transition state of many reactions and can be used to obtain catalytic antibodies. The functionalized heteroarylsubstituted phosphinic acids which have been used as hapten precursors were obtained by phosphorylation of 1-alkyl-5-nitrobenzimidazole or by usage of a new phosphorylating reagent - (4-trichloromethylphenyl)phosphonic dichloride.
Synthesis and antimicrobial activity of substituted benzimidazole, benzothiazole and imidazole derivatives
Kucukbay,Cetinkaya,Durmaz
, p. 1331 - 1334 (2007/10/02)
New benzimidazole, benzothiazole and imidazole derivatives were synthesized by reacting electron-rich olefins (5, 23 and 29) with appropriate reagents. The compounds synthesized were identified by 1H, 13C-NMR, FT-IR and mass spectros
