197516-48-6

Basic information

• Product Name: 5-HYDRAZINYL-2-METHYLPYRIDINE
• Synonyms: 1-(6-METHYLPYRIDIN-3-YL)HYDRAZINE;5-HYDRAZINYL-2-METHYLPYRIDINE;(6-METHYL-PYRIDINE-3-YL)-HYDRAZINE;(6-METHYL-PYRIDIN-3-YL)-HYDRAZINE;Pyridine,5-hydrazino-2-methyl;Pyridine, 5-hydrazino-2-methyl- (9CI);5-Hydrazino-2-methylpyridine;5-Hydrazino-2-Methyl
• CAS NO: 197516-48-6
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• EINECS: 125-859-9
• Product Categories: PYRIDINE;Pyridines
• Mol File: 197516-48-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 261.102 °C at 760 mmHg
• Flash Point: 111.711 °C
• Appearance: /
• Density: 1.167 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.633
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-HYDRAZINYL-2-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDRAZINYL-2-METHYLPYRIDINE(197516-48-6)
• EPA Substance Registry System: 5-HYDRAZINYL-2-METHYLPYRIDINE(197516-48-6)

Safety Data

• Hazardous Substances Data: 197516-48-6(Hazardous Substances Data)

Usage

General Description

5-Hydrazinyl-2-methylpyridine is a synthetic chemical compound that is categorized under the class of organic compounds known as hydrazine derivatives. Given that it is a derivative of hydrazine, it contains a hydrazinyl functional group, which is formed from two nitrogen atoms bonded together, along with a methyl and pyridine ring. Pyridine is a basic heterocyclic organic compound, similar to benzene and nitrogen, but having one methine group replaced by a nitrogen atom. This chemical can be used in various chemical reactions and processes in industries. Safety measures should be taken while handling this chemical as it may pose hazards on ingestion, inhalation or skin contact. Specific properties such as melting point, boiling point, or solubility can vary based on its synthesized form.

InChI:InChI=1/C6H9N3/c1-5-2-3-6(9-7)4-8-5/h2-4,9H,7H2,1H3

Upstream product

• 21203-68-9 2-methyl-5-nitropyridine 

Downstream Products

• 875553-83-6 1-(6-methylpyridin-3-yl)-5-(1-phenylsulfonyl-1H-pyrrol-3-yl)-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Structure-Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy) naphthalen-1-yl]urea (BIRB 796)

We report on the structure-activity relationships (SAR) of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy) naphthalen-1-yl]urea (BIRB 796), an inhibitor of p38α MAP kinase which has advanced into human clinical trials for the treatment of autoimmune diseases. Thermal denaturation was used to establish molecular binding affinities for this class of p38α inhibitors. The tert-butyl group remains a critical binding element by occupying a lipophilic domain in the kinase which is exposed upon rearrangement of the activation loop. An aromatic ring attached to N-2 of the pyrazole nucleus provides important π-CH 2 interactions with the kinase. The role of groups attached through an ethoxy group to the 4-position of the naphthalene and directed into the ATP-binding domain is elucidated. Pharmacophores with good hydrogen bonding potential, such as morpholine, pyridine, and imidazole, shift the melting temperature of p38α by 16-17 °C translating into Kd values of 50-100 pM. Finally, we describe several compounds that potently inhibit TNF-α production when dosed orally in mice.