197520-71-1

Basic information

• Product Name: 2,3,4-Trifluoro-5-Nitro-Benzoic Acid
• Synonyms: 2,3,4-Trifluoro-5-Nitro-Benzoic Acid
• CAS NO: 197520-71-1
• Molecular Formula: C₇H₂F₃NO₄
• Molecular Weight: 221.0902896
• Mol File: 197520-71-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 349.678 °C at 760 mmHg
• Flash Point: 165.279 °C
• Appearance: /
• Density: 1.748
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• PKA: 2.30±0.12(Predicted)
• CAS DataBase Reference: 2,3,4-Trifluoro-5-Nitro-Benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-Trifluoro-5-Nitro-Benzoic Acid(197520-71-1)
• EPA Substance Registry System: 2,3,4-Trifluoro-5-Nitro-Benzoic Acid(197520-71-1)

Safety Data

• Hazardous Substances Data: 197520-71-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow powder

InChI:InChI=1/C7H2F3NO4/c8-4-2(7(12)13)1-3(11(14)15)5(9)6(4)10/h1H,(H,12,13)

Upstream product

• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 284030-63-3 2,3-difluoro-4-hydroxy-5-nitrobenzoic acid 
• 219796-67-5 2.4-bis-(2-Chloro-4-iodo-phenylamino)-3-fluoro-5-nitrobenzoic Acid 
• 197520-72-2 N-benzyloxycarbonyl-2,3,4-trifluoro-5-nitroaniline 
• 606093-59-8 7-Fluoro-6-phenylamino-3H-benzoimidazole-5-carboxylic acid methyl ester 
• 606144-42-7 4,5-diamino-3-fluoro-2-phenylamino-benzoic acid methyl ester 
• 606093-58-7 4-Amino-3-fluoro-5-nitro-2-phenylamino-benzoic acid methyl ester 

Relevant articles and documents

An efficient synthesis of 5-chloro-2, 3, 4-trifluorobenzoic acid

5-Chloro-2, 3, 4-trifluorobenzoic acid, a key intermediate for preparing quinolone-3-carboxylic acid derivatives, was synthesised from the commercially available 2, 3, 4, 5-trifluorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.

Substituted benzimidazole compound and composition with compound

The invention provides a substituted benzimidazole compound and a composition with the compound. The substituted benzimidazole compound is a compound of formula (I) as shown in the specification, or apharmaceutically acceptable salt, prodrug, aquo-complex or solvent compound, polycrystalline type compound, stereisomer or isotope variant of the compound. The compound provided by the invention canbe adopted to treat and/or prevent related diseases caused by MEK (Methyl Ethyl Ketone), such as excessive proliferative diseases, pancreatitis, kidney illness, blastocyte cell transplantation and angiogenesis or angiopoiesis related diseases.

INHIBITORS OF MEK

This invention concerns to N-(2-aylamino) aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds.