197520-90-4Relevant articles and documents
AN EASY SYNTHESIS OF MONOMETHYL MALONATE DERIVATIVES
Matoba, Katsuhide,Yamazaki, Takao
, p. 2955 - 2956 (2007/10/02)
Monomethyl malonates (IIIa-c and Va) were synthesized from Meldrum's acid (Ia) by treating with an excess of diazomethane in the corresponding alcohols and piperidine, respectively, in quantitative yields.In a similar manner, 5-p-chlorobenzyl Meldrum's acid (Ib) afforded the corresponding monomethyl malonate derivatives (IIIe, f, and Vb).The mechanism proposed for this reaction is described.KEYWORDS - Meldrum's acid; monomethyl malonate; half ester; ketene ester; 4,6-dioxo-1,3-dioxane