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19754-57-5

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19754-57-5 Usage

General Description

2-[(8-Chlorooctyl)oxy]tetrahydro-2H-pyran, also known as 8-chlorooctyl tetrahydro-2H-pyran-2-yl ether, is a chemical compound with the molecular formula C12H23ClO2. It is a clear, colorless liquid that is insoluble in water but soluble in organic solvents. 8-chlorooctyl tetrahydro-2H-pyran-2-yl ether is commonly used as a reagent in organic synthesis and as a building block in the production of pharmaceuticals and other chemical compounds. It is also utilized as a solvent and in the manufacture of flavor and fragrance compounds. 2-[(8-Chlorooctyl)oxy]tetrahydro-2H-pyran is known to have low toxicity and is considered to be relatively safe for use in controlled laboratory settings when handled and disposed of according to proper safety guidelines.

Check Digit Verification of cas no

The CAS Registry Mumber 19754-57-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,7,5 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 19754-57:
(7*1)+(6*9)+(5*7)+(4*5)+(3*4)+(2*5)+(1*7)=145
145 % 10 = 5
So 19754-57-5 is a valid CAS Registry Number.
InChI:InChI=1/C13H25ClO2/c14-10-6-3-1-2-4-7-11-15-13-9-5-8-12-16-13/h13H,1-12H2

19754-57-5Relevant articles and documents

Improved synthesis of unique estradiol-linked platinum(II) complexes showing potent cytocidal activity and affinity for the estrogen receptor alpha and beta

Descoteaux, Caroline,Leblanc, Valerie,Belanger, Geoffroy,Parent, Sophie,Asselin, Eric,Berube, Gervais

, p. 1077 - 1089 (2008)

We have recently reported the synthesis of a platinum(II) complex, made of estradiol, the female sex hormone, and a cisplatin analog, an anticancer drug, linked together by an eleven carbon atoms chain. The novel estradiol-Pt(II) hybrid molecule was synthesized in nine chemical steps with 10% overall yield. This new compound has been tested in vitro on estrogen-dependent (MCF-7) and -independent (MDA-MD-231) (ER+ and ER-) cell lines. Interestingly, the biological activity was quite significant, more potent than that of cisplatin, the compound currently used in chemotherapy. The estrogen receptor binding affinity (ERBA) of this compound was very similar to that of 17β-estradiol (E2) on both estrogen receptors (ERs), α and β. In order to further study this type of molecule, we have decided to synthesize several analogs with the same estrogenic scaffold but with various chain lengths separating the estradiol from the toxic part of the molecule. This was planned in order to study the effect of the length of the linking chain on the biological activity of the hybrids. Four E2-Pt(II) hybrid molecules having 6-14 carbon atoms linking chain have been synthesized using a new synthetic methodology. They are synthesized in only eight chemical steps with 21% overall yield. The 17β-estradiol-linked platinum(II) complexes have been tested for their receptor binding affinity as well as for their cytocidal activity on several breast cancer cell lines. The synthesis and biological results are reported herein.

Improved synthesis of (9Z)-9,13-tetradecadien-11-ynal, the sex pheromone of the avocado seed moth, Stenoma catenifer

Zou, Yunfan,Millar, Jocelyn G.

, p. 1336 - 1337 (2010)

The terminal dienyne of (9Z)-9,13-tetradecadien-11-ynal, the sex pheromone of the avocado seed moth, Stenoma catenifer, was constructed by coupling a vinyl iodide precursor with commercially available 1-buten-3-yne with Pd catalysis, resulting in a short and efficient synthesis of the pheromone.

Ethynylation of the ether derivatives of ω-haloalkanols with lithium acetylide-ethylenediamide complex

Karpinska,Lewandowska,Grodner

, p. 937 - 942 (2007/10/03)

A new operationally simple and highly efficient procedure for the ethynylation of ether derivatives of ω-haloalkanols with lithium acetylide-ethylenediamine complex in N,N-dimethylacetamide is described.

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