19757-13-2Relevant articles and documents
Electrochemical synthesis of sulfamides
Blum, Stephan P.,Sch?ffer, Lukas,Schollmeyer, Dieter,Waldvogel, Siegfried R.
supporting information, p. 4775 - 4778 (2021/05/25)
Herein we demonstrate the first electrochemical synthesis protocol of symmetrical sulfamides directly from anilines and SO2mediated by iodide. Sulfamides are an emerging functional group in drug design. Highlights are the direct use of SO2from a stock solution and no necessity of any supporting electrolyte. Overall, the reaction has been demonstrated for 15 examples with yields up to 93%.
Investigation of the acid-catalyzed hydrolysis and reaction mechanisms of N,N′-diarylsulfamides using various criteria
Bekdemir, Yunus,Erturk, Aliye Gediz,Kutuk, Halil
, p. 94 - 98 (2014/02/14)
The mechanism of acid-catalyzed hydrolysis of a series of p-substituted N,N′-diarylsulfamides was investigated in aqueous mineral acid solutions. Rate profiles, reaction activation parameters, catalytic order of strong acids, solvent isotope effects, and analysis of the kinetic data by the excess acidity method suggest a change in the mechanism from A2 to A1. While the hydrolysis proceeds with an A2 mechanism in low acidity regions, an A1 mechanism takes place in high acid concentrations. Copyright
