197582-19-7

Basic information

• Product Name: Ethyl 4-methyl-5-oxo-2-phenylsulfanylthiocarbonyl-2,5-dihydroisoxazole-3-carboxylate
• Synonyms: Ethyl 4-methyl-5-oxo-2-phenylsulfanylthiocarbonyl-2,5-dihydroisoxazole-3-carboxylate
• CAS NO: 197582-19-7
• Molecular Weight: 323.394
• Mol File: 197582-19-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Ethyl 4-methyl-5-oxo-2-phenylsulfanylthiocarbonyl-2,5-dihydroisoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-methyl-5-oxo-2-phenylsulfanylthiocarbonyl-2,5-dihydroisoxazole-3-carboxylate(197582-19-7)
• EPA Substance Registry System: Ethyl 4-methyl-5-oxo-2-phenylsulfanylthiocarbonyl-2,5-dihydroisoxazole-3-carboxylate(197582-19-7)

Safety Data

• Hazardous Substances Data: 197582-19-7(Hazardous Substances Data)

Upstream product

• 16911-89-0 phenyl chlorodithioformate 
• 84280-59-1 ethyl 4-methyl-5-oxo-2,5-dihydro-1,2-oxazole-3-carboxylate 

Relevant articles and documents

The chemistry of 5-oxodihydroisoxazoles. Part 22. The synthesis of 1,3-oxazin-6-ones from N-thioacylisoxazol-5(2H)-ones

N-Thioacylisoxazol-5(2H)-ones, prepared by the reaction of thiocarbonyl chlorides with isoxazol-5(2H)-ones in the presence of base, are reduced by triphenylphosphine to afford 1,3-oxazin-6-ones and triphenylphosphine sulfide. If the thioacylation is carried out with phenyl chlorodithioformate, the thermal rearrangement of the intermediate, to again form the oxazin-6-one and sulfur, is so rapid that the use of the phosphine is not required. The presence of an ethoxycarbonyl group at C-3, or of a bromine atom at C-4 of the isoxazolone results in the formation of thiazoles.