197662-98-9Relevant academic research and scientific papers
Synthesis of E- and Z-Pyrazolylacrylonitriles and their evaluation as novel antioxidants
Parmar, Virinder S.,Kumar, Ajay,Prasad, Ashok K.,Singh, Sanjay K.,Kumar, Naresh,Mukherjee, Shubhasish,Raj, Hanumantharao G.,Goel, Sanjay,Errington, William,Puar, Mohindar S.
, p. 1425 - 1436 (2007/10/03)
A facile synthesis of (Z)- and (E)-2-(5-arylpyrazol-3-yl)-3-(pyrrol-2-yl)acrylonitriles and (Z)-2-(1,3-diarylpyrazol-5-yl)-3-(pyrrol-2-yl)acrylonitriles, and isomerisation of (Z)-2-(5-arylpyrazolyl)acrylonitriles to (E)-2-(5-arylpyrazolyl)acrylonitriles under basic conditions have been reported. (Z)-2-(1,3-Diarylpyrazolyl)acrylonitriles did not undergo isomerisation under the similar conditions. New compounds were identified on the basis of their spectral data (1H-, 13C-, 1H-1H COSY, NOESY, NOE, HMQC NMR, IR, UV and EI mass). The structures of one acrylonitrile and five of their precursor 6-arylpyran-2-ones and cyanomethylpyrazoles were confirmed by X-ray crystallographic studies. Effects of pyrazolylacrylonitriles and their precursors on rat liver-microsomal lipid peroxidation were evaluated in vitro with a view to establish structure-activity relationship and to identify a lead compound. Copyright (C) 1999 Elsevier Science Ltd.
Synthetic and mass spectral fragmentation studies on trisubstituted 2H-pyran-2-ones and comparative EIMS behaviour of biologically active 3,5-disubstituted pyrazoles and isoxazoles
Parmar, Virinder S.,Jain, Subhash C.,Jha, Amitabh,Kumar, Naresh,Kumar, Ajay,Vats, Archana,Jha, Hriday N.,Mukherjee, Shubhasish,Singh, Sanjay K.,Jennings, Keith R.,Summerfield, Scott G.,Errington, William,Olsen, Carl E.
, p. 872 - 879 (2007/10/03)
Eight 3-cyano-4-thiomethyl-6-aryl-2H-pyran-2-ones 1-8 and three 3-cyano-4-(N,N-dimethy)amino-6-aryl-2H-pyran-2-ones 9-11 have been synthesised and their detailed mass fragmentation pattern alongwith the X-ray crystal structure of a novel pyrone 5 have been studied. In addition, a comparative EIMS behaviour of 3,5-disubstituted pyrazoles 16-23 and isoxazoles 12-15 is reported. The pyrazole derivative 23 has been found to possess strong anti-invasive activity against human breast carcinoma cells.
