19773-24-1

Basic information

• Product Name: peimisine
• Synonyms: (2'R,3S,3'R,3'aS,4aS,6'S,6aR,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',4a,5',6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3-hydroxy-3',6',10,11b-tetraMethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-5(6H)-one;(3β)-17,23-Epoxy-3-hydroxy veratraMan-6(5H)-one;11-Deoxo-6-oxo-5α,6-dihydrojervine;Spiro[9H-benzo[a]fluorene-9,2;Peimisine, 98%, from Fritillaria cirrhosa D. Don
• CAS NO: 19773-24-1
• Molecular Formula: C27H41NO3
• Molecular Weight: 427.625
• Product Categories: Pharmaceuticals;Steroids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Intermediates & Fine Chemicals
• Mol File: 19773-24-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 270℃
• Boiling Point: 573 °C at 760 mmHg
• Flash Point: 300.3 °C
• Appearance: /
• Density: 1.17
• Refractive Index: 1.577
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.89±0.70(Predicted)
• CAS DataBase Reference: peimisine(CAS DataBase Reference)
• NIST Chemistry Reference: peimisine(19773-24-1)
• EPA Substance Registry System: peimisine(19773-24-1)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 19773-24-1(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 19773-24-1 differently. You can refer to the following data:
1. An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. Peimisine is a commonly used antitussive and expectorant herb in traditional Chinese medicine.
2. An alkaloid FR 5 from Fritillaria thunbergii. An angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant herb in traditional Chinese medicine.

InChI:InChI=1/C27H41NO3/c1-14-9-24-25(28-13-14)16(3)27(31-24)8-6-18-19(15(27)2)11-21-20(18)12-23(30)22-10-17(29)5-7-26(21,22)4/h14,16-18,20-22,24-25,28-29H,5-13H2,1-4H3/t14-,16+,17-,18+,20-,21-,22?,24?,25-,26+,27-/m0/s1

Related news

peimisine (cas 19773-24-1) and peiminine production by endophytic fungus Fusarium sp. isolated from Fritillaria unibracteata var. wabensis09/04/2019

Steroidal alkaloids, as the major biologically active components in Bulbus Fritillariae, possess a variety of toxicological and pharmacological effects on humans. The objective of this work was to determine whether endophytic fungi isolated from fresh bulbs of Fritillaria unibracteata var. waben...detailed

Fusarium redolens 6WBY3, an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis, produces peimisine (cas 19773-24-1) and imperialine-3β-d-glucoside09/03/2019

The major biological active ingredients of Bulbus Fritillariae cirrhosae (BFC) are steroidal alkaloids, such as peimisine, imperialine-3β-d-glucoside, and peimine. The bulbus of Fritillaria unibracteata var. wabuensis (FUW) was officially recorded in the National Pharmacopoeia of China (2010 ed...detailed

A convenient and efficient one-pot conversion of peimisine (cas 19773-24-1) into cyclopamine09/02/2019

A convenient and efficient one-pot synthesis of cyclopamine from peimisine is described. The key steps involve one-pot hydrazination and subsequent Bamford–Stevens reaction. The mild reaction conditions, high overall yield as well as an easy purification indicate this process can potentially be...detailed

Relevant articles and documents

Steroidal alkaloids from the bulbs of Fritillaria unibracteata

Two new steroidal alkaloids peimisine-3-O-β-D-glucopyranoside (1) and puqiedinone- 3-O-β-D-glucopyranoside (3), together with three known compounds peimisine (2), puqiedinone (4), and puqiedine (5), were isolated and characterized from the bulbs of Fritillaria unibracteata. Their structures were fully elucidated by spectroscopic and chemical methods. Compound 1 showed moderate protection effect on neurotoxicity of PC12 cell lines induced by rotenone.