1977495-97-8 Usage
General Description
G1T28 is a small molecule inhibitor that selectively targets and inhibits the enzyme CDK4/6, which are key regulators of the cell cycle and play a critical role in promoting cancer cell proliferation. By inhibiting CDK4/6, G1T28 has the potential to disrupt the uncontrolled growth of cancer cells, thereby slowing down or even halting the progression of certain types of cancer. G1T28 has shown promising results in preclinical studies and is currently being evaluated in clinical trials as a potential treatment option for various types of cancer, particularly those that are driven by aberrant cell cycle regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 1977495-97-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,7,7,4,9 and 5 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1977495-97:
(9*1)+(8*9)+(7*7)+(6*7)+(5*4)+(4*9)+(3*5)+(2*9)+(1*7)=268
268 % 10 = 8
So 1977495-97-8 is a valid CAS Registry Number.
1977495-97-8Relevant articles and documents
COMBINATIONS AND DOSING REGIMES TO TREAT RB-POSITIVE TUMORS
-
Page/Page column 153; 156-157; 159, (2016/06/01)
This invention directed to methods for treating select RB-positive cancers and other Rb- positive abnormal cellular proliferative disorders using CDK4/6 inhibitors in specific dosing and combination or alternation regimes. In one aspect, treatments of select RB-positive cancers are disclosed using specific CDK4/6 inhibitors in combination or alternation with another chemotherapeutic, for example, an additional kinase inhibitor, PD-1 inhibitor, or BCL-2 inhibitor, or combination thereof.
