197771-13-4

Upstream product

• 129144-90-7 2-methyl-4-(triphenyl-λ⁵-phosphoranylidene)but-2-enoic acid methyl ester 
• 197771-12-3 [(2R,4R,6S)-2-((S)-1-Methyl-2-oxo-ethyl)-6-phenylsulfanyl-tetrahydro-pyran-4-yl]-acetonitrile 
• 197771-09-8 {(2R,4R)-2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-6-ethoxy-tetrahydro-pyran-4-yl}-acetonitrile 
• 197771-11-2 {(2R,4R,6S)-2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-6-phenylsulfanyl-tetrahydro-pyran-4-yl}-acetonitrile 
• 197771-04-3 (5R,4R)-6-tert-butyldimethylsilyloxy-5-methyl-4-(4-nitrobenzoyloxy)hex-1-ene 
• 197771-03-2 (5R,4R)-6-hydroxy-5-methyl-4-(4-nitrobenzoyloxy)hex-1-ene 
• 197770-99-3 (E)-(5R,6R)-7-(tert-Butyl-dimethyl-silanyloxy)-5-(1-ethoxy-2-iodo-ethoxy)-6-methyl-hept-2-enenitrile 
• 197771-16-7 [(2R,4R,6S)-2-((R)-2-Hydroxy-1-methyl-ethyl)-6-phenylsulfanyl-tetrahydro-pyran-4-yl]-acetonitrile 
• 197771-08-7 (3R,4R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-(1-ethoxy-2-iodo-ethoxy)-4-methyl-pentanal 
• 197771-06-5 tert-Butyl-[(2R,3R)-3-(1-ethoxy-2-iodo-ethoxy)-2-methyl-hex-5-enyloxy]-dimethyl-silane 
• 197771-01-0 (5R,4R)-6-benzyloxy-5-methyl-4-(4-nitrobenzoyloxy)hex-1-ene 
• 112897-05-9 (5R,4R)-6-tert-butyldimethylsilyloxy-4-hydroxy-5-methylhex-1-ene 
• 94233-74-6 (2R,3S)-1-(benzyloxy)-2-methylhex-5-en-3-ol 

Downstream Products

• 197771-14-5 [(2R,4R,6S)-2-((2E,4E)-(R)-1,5-Dimethyl-6-oxo-hexa-2,4-dienyl)-6-phenylsulfanyl-tetrahydro-pyran-4-yl]-acetonitrile 
• 197771-15-6 [(2R,4R,6S)-2-((2E,4E)-(R)-6-Hydroxy-1,5-dimethyl-hexa-2,4-dienyl)-6-phenylsulfanyl-tetrahydro-pyran-4-yl]-acetonitrile 

Relevant academic research and scientific papers

Studies on the total synthesis of the macrolide antitumor agent rhizoxin. 1. Synthesis of the C3-C13 segment

An asymmetric synthesis of the C3-C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a phot