1978-21-8Relevant articles and documents
Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E
Gonay, Marie,Batisse, Chloé,Paquin, Jean-Fran?ois
, p. 10253 - 10260 (2020/08/12)
The synthesis of acyl fluorides using the deoxofluorination reaction of carboxylic acids using XtalFluor-E is described. This transformation, assisted by a catalytic amount of NaF, occurs at room temperature in EtOAc, where XtalFluor-E behaves as the activating agent and the fluoride source. A wide range of acyl fluorides were obtained in moderate to excellent yields (36-99%) after a simple filtration on a pad of silica gel. We also demonstrated that sequential deoxofluorination/amidation was possible.
Catalytic Acid Fluoride Synthesis via Carbonylation of Organic Bromides in the Presence Potassium Fluoride
Okano, Tamon,Harada, Nobuyuki,Kiji, Jitsuo
, p. 1741 - 1743 (2007/10/02)
Various aryl bromides were carbonylated under an atmospheric pressure of carbon monoxide in DMF in the presence of potassium fluoride to give aroyl fluorides in excellent yields.The carbonylation was promoted by the addition of phase transfer catalysts, but the contamination with water reduced the selectivity.