1978-68-3Relevant academic research and scientific papers
Visible-Light Mediated ortho-Trifluoromethylation of Aniline Derivatives
Tian, Chao,Wang, Qiyue,Wang, Xueqi,An, Guanghui,Li, Guangming
, p. 14241 - 14247 (2019/10/16)
A general visible-light mediated ortho-C-H trifluoromethylation of aniline derivatives by using a low-cost and stable Langlois reagent (CF3SO2Na) as the "CF3" source has been developed. In contrast to previous reports, this strategy allowed access to elusive trifluoromethyl lactams. Furthermore, mechanism experiments revealed that a copper/photoredox dual catalytic mechanism enabled general trifluoromethylation of aniline derivatives.
Quinoline-3-carboxamides
-
, (2008/06/13)
Novel quinoline-3-carboxamides of the formula STR1 wherein R1 is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, --CF3, --OCF3, --SCF3, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms and alkoxy of 1 to 4 carbon atoms, R2 is selected from the group consisting of hydrogen and methyl, R3 is selected from the group consisting of thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl and imidazolyl and R4 is selected from the group consisting of hydrogen, hydroxyl, alkyl of 1 to 4 carbon atoms, phenyl and benzyl with the proviso that when R1 is in the 7 or 8-position and is halogen, --CH3, --OCF3 or --SCF3 and R4 is hydrogen, R3 is not thiazolyl, pyridinyl or oxazolyl and the non-toxic, pharmaceutically acceptable acid addition salts when R3 is imidazolyl or 4,5-dihydrothiazolyl having analgesic activity and their preparation and novel intermediates therefore.
