19781-28-3Relevant articles and documents
Enantioselective butylation of aliphatic aldehydes by mixed chiral lithium amide/n-BuLi dimers
Arvidsson, Per I.,Davidsson, Oejvind,Hilmersson, Goeran
, p. 527 - 534 (2007/10/03)
The enantioselective butylation of aliphatic aldehydes with mixtures of n-butyllithium and chiral lithium amides in a diethyl ether-dimethoxymethane solvent mixture is described. Enantiomeric excesses ranging from 91 to 98.5% were observed for several aliphatic alcohols. The asymmetric butylation of the prochiral aldehydes proceeds much faster by the mixed lithium amide/n- BuLi complexes than by tetrameric n-BuLi.