197846-61-0

Upstream product

• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 1416159-34-6 4-(4-methoxyphenyl)-1-(4-nitrophenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole 
• 1638156-70-3 5-(4-methoxyphenyl)-2-phenyl-4-[(trimethylsilyl)ethynyl]pyrimidine 
• 1638156-66-7 4-ethynyl-2,5-bis(4-methoxyphenyl)pyrimidine 
• 1638156-65-6 4-ethynyl-5-(4-methoxyphenyl)-2-(4-methylphenyl)pyrimidine 
• 1638156-64-5 4-ethynyl-5-(4-methoxyphenyl)-2-phenylpyrimidine 
• 1638156-63-4 2-(4-chlorophenyl)-4-ethynyl-5-(4-methoxyphenyl)pyrimidine 
• 1638156-62-3 4-ethynyl-5-(4-methoxyphenyl)-2-(4-nitrophenyl)pyrimidine 
• 1489239-43-1 1-(1-(4-methoxyphenethyl)-1H-1,2,3-triazol-4-yl)-2-(4-methoxyphenyl)ethane-1,2-dione 
• 1489239-48-6 1-(1-(4-methoxyphenethyl)-1H-1,2,3-triazol-4-yl)-2-(4-methoxyphenyl)ethanone 
• 1489239-42-0 1-(4-methoxyphenyl)-2-(1-phenethyl-1H-1,2,3-triazol-4-yl)ethane-1,2-dione 
• 1489239-47-5 2-(4-methoxyphenyl)-1-(1-phenethyl-1H-1,2,3-triazol-4-yl)ethanone 
• 1357356-79-6 1-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(4-methoxyphenyl)ethane-1,2-dione 
• 1416159-33-5 4-(4-methoxyphenyl)-1-phenyl-5-(trimethylsilyl)ethynyl-1H-pyrazole 
• 1416159-32-4 1,4-bis(4-methoxyphenyl)-5-(trimethylsilyl)ethynyl-1H-pyrazole 

Relevant academic research and scientific papers

Transition-metal-free approach to 4-ethynylpyrimidines via alkenynones

A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4- yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%. Copyright

Synthesis of [2-(Trimethylsilyl)ethynyl]pyrazoles based on bis(trimethylsilyl)acetylene and arylacetyl chlorides

A practical approach to the synthesis of [2-(trimethylsilyl)ethynyl] pyrazoles was developed through condensation of hydrazines with enynones that are easily accessible frombis(trimethylsilyl)acetylene and arylacetyl chlorides. Optimized conditions for reactions with monoarylhydrazines permit the chemoselective formation of 5-alkynylpyrazoles in high yields (48-94 %). When monoalkylhydrazines or the parent hydrazine is used, mixtures of 3- and 5-alkynylpyrazoles are formed in 73-79 % yields. The method uses inexpensive starting materials and can be applied to a variety of substrates, which makes it convenient for the synthesis of alkynylpyrazoles. A three-step method for the synthesis of 5-alkynylpyrazoles through a transformation of bis(trimethylsilyl) acetylene to enynones followed by their condensation with hydrazines is described. The chemoselectivity of the last stage is discussed.

Synthesis of α,β-diketotriazoles by aerobic copper-catalyzed oxygenation with triazole as an intramolecular assisting group

The catalytic oxidation of α-ketotriazoles to α,β- diketotriazoles was performed with CuCl2 or CuI/2,9-dimethyl-1,10- phenanthroline in air at 80 °C in good yields. Studies showed that the triazole group participates in complexation to the copper and favors oxidation. Copyright

Applications of the spiroannulation of tetralins with alkynes; towards new anti-estrogenic compounds

Thermal reaction of the benzocyclobutene 17 with 4-methoxystyrene leads to 1-cyano-2-(4-methoxyphenyl)-6-methoxytetralin? 19 through an electrocyclic ring opening Diels-Alder sequence: the derived acid chloride 20, and its analogue 10, then undergoes an u