19785-39-8

Usage

InChI:InChI=1/C6H6N2S/c1-5-4-9-6(8-5)2-3-7/h4H,2H2,1H3

Upstream product

• 50398-72-6 2-(chloromethyl)-4-methylthiazole 
• 143-33-9 sodium cyanide 
• 7357-70-2 Cyanothioacetamide 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 

Downstream Products

• 147642-48-6 3-Amino-2-benzyl-4-(4-methyl-thiazol-2-yl)-7-nitro-2H-isoquinolin-1-one 
• 125103-17-5 2-Amino-1-benzyl-3-(4-methylthiazol-2-yl)pyrrolo<2,3-b>quinoxaline 
• 117840-81-0 methyl (4-methyl-1,3-thiazol-2-yl)acetate 
• 1228017-70-6 4-(4-methyl-1,3-thiazol-2-yl)-1-phenyl-1H-1,2,3-triazol-5-amine 
• 1159942-71-8 4-(4-methylthiazol-2-yl)-1H-pyrazol-5-amine 
• 1607023-08-4 5-(4-chlorophenyl)-3-(4-methylthiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 1607023-54-0 5-(3,4-dichlorophenyl)-3-(4-methylthiazol-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one 
• 137811-96-2 1-(2,4-dihydroxy-5-propylphenyl)-2-(4-methylthiazol-2-yl)ethan-1-one 
• 170466-84-9 6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-one 
• 170466-78-1 1-(2,4-dihydroxy-5-ethylphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone 
• 75896-41-2 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone 

Relevant academic research and scientific papers

NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF

The present invention relates to novel hydrazone derivatives in which a terminal amine group is substituted with an aryl group or a heteroaryl group, and uses thereof.

Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof

The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.

Enantioselective Reaction between 2-(Cyanomethyl)azaarenes and N-Boc-amino Sulfones

A series of 2-(cyanomethyl)azaarenes containing benzothiazole or benzoxazole were designed and synthesized for asymmetric α-functionalization with N-Boc-amino sulfones. The Mannich adducts were obtained in high yields with good diastereo- and enantioselectivities. Aryl-substituted amino sulfones were tolerated under the current conditions, and the reaction can be performed on gram scale in good results.

COMPOUNDS, COMPOSITIONS, AND METHODS

The present disclosure relates generally to compounds of formula (I) or a pharmaceutically acceptable salt, prodrug, deuterated analog, tautomer, stereoisomer, or mixture of stereoisomers thereof and their use as LRRK2 inhibitors.

HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK

Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.

DERIVATIVES OF CHROMEN-2-ONE AS INHIBITORS OF VEGF PRODUCTION IN MAMMALIAN CELLS

The compounds of formula (I) wherein A and R1-R5 are as defined in the description, are inhibitors of Vascular Endothelial Growth Factor and are useful as angiogenesis inhibitors and antiproliferative agents.

AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS

The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.