19786-58-4

Basic information

• Product Name: 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester
• Synonyms: 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester
• CAS NO: 19786-58-4
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 258.2909
• Mol File: 19786-58-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 365.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.41±0.20(Predicted)
• CAS DataBase Reference: 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester(19786-58-4)
• EPA Substance Registry System: 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester(19786-58-4)

Safety Data

• Hazardous Substances Data: 19786-58-4(Hazardous Substances Data)

Usage

General Description

1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester is a chemical compound with the molecular formula C14H23NO4. It is an ester of a hexahydro-5-oxo-1H-azepine-1,4-dicarboxylic acid. 1H-Azepine-1,4-dicarboxylic acid, hexahydro-5-oxo-, 1,4-diethyl ester is commonly used as a pharmaceutical intermediate and can be found in various drugs and medications. It is known for its potential therapeutic properties, including its use as an anticonvulsant and anxiolytic. Furthermore, studies have also shown its potential as a treatment for various neurological disorders. However, the compound is known to be toxic if ingested or inhaled, and proper safety precautions should be followed when handling it.

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
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• 1972-28-7 diethylazodicarboxylate 

Relevant articles and documents

Discovery of β-Arrestin Biased Ligands of 5-HT7R

Though many studies have been published about therapeutic potentials of selective 5-HT7R ligands, there have been few biased ligands of 5-HT7R. The development of potent and selective biased ligands of 5-HT7R would be of great help in understanding the relationship between pharmacological effects and G protein/β-arrestin signaling pathways of 5-HT7R. In order to identify 5-HT7R ligands with biased agonism, we designed and synthesized a series of tetrahydroazepine derivatives 1 and 2 with arylpyrazolo moiety or arylisoxazolo moiety. Through several biological evaluations such as binding affinity, selectivity profile, and functions in G protein and β-arrestin signaling pathways, 3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine 1g was discovered as the β-arrestin biased ligand of 5-HT7R. In an electroencephalogram (EEG) test, 1g increased total non-rapid eye movement (NREM) sleep time and decreased total rapid eye movement (REM) sleep time.

The discovery of azepane sulfonamides as potent 11β-HSD1 inhibitors

Discovery of a series of azepine sulfonamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is described. SAR studies at the 4-position of the azepane ring have resulted in the discovery of a very potent compound 30 which has

Pentacyclic kinase inhibitors

The invention provides novel kinase inhibitors that are useful as therapeutic agents for example in the treatment malignancies where the compounds have the general formula I wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2, R3 and m are defined herein.