197862-46-7

Upstream product

• 197862-42-3 2-But-3-enyl-4-phenylsulfanyl-2,5-dihydro-thiophene 1,1-dioxide 
• 64741-13-5 3-thiophenyl-3-sulfolene 
• 197862-44-5 4-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-butan-1-ol 

Downstream Products

• 197862-50-3 6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-one 
• 197862-48-9 6-(1,1-Dioxo-4-phenylsulfanyl-2,5-dihydro-1H-1λ⁶-thiophen-2-yl)-hex-1-en-3-ol 

Relevant academic research and scientific papers

Intramolecular Cycloaddition of Nitrones and Nitrile Oxides with Sulfur-Substituted Dienes and Its Synthetic Applications

A series of sulfur-substituted dienyl nitrones and oximes were conveniently prepared from the 3-sulfolene precursors. Regiospecific intramolecular 1,3-dipolar cycloadditions of nitrones and nitrile oxides with sulfur-substituted dienes have been efficiently carried out from the suitable 3-sulfolene precursors. The stereochemistry of the cycloaddition of nitrones depends on the structure of the substituent (sulfide or sulfone) on the diene as well as on the chain length connecting the diene and nitrone. The fused bicyclic products obtained from these reactions have been converted to some interesting heterocyclic compounds which have the useful structure of vinyl sulfide or sulfone.

Intramolecular Diels-Alder Reactions of Thio-Substituted Dienes with Enones

Thio-substituted dienes bearing an enone moiety were readily prepared from 3-sulfolenes, and their intramolecular Diels-Alder (IMDA) reactions were studied. Octahydronaphthalenones were produced in good yield with high stereoselectivity. Hexahydroindenones were also obtained, but the stereoselectivity was lower.

Intramolecular cycloaddition of nitrones with sulfur-substituted dienes and its synthetic applications

A series of sulfur-substituted dienyl nitrones were conviently prepared from the 3-sulfolene precursors. Intramolecular 1,3-dipolar cycloaddition reactions gave the fused bicyclic isoxazolidines. The regio- and stereochemical outcome of these reactions as well as the synthetic applications have been explored.