197891-67-1

Upstream product

• 501-53-1 benzyl chloroformate 
• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 24424-99-5 di-tert-butyl dicarbonate 
• 197891-66-0 4-benzyloxycarbamate-butyraldehyde diethyl acetal 

Downstream Products

• 197891-70-6 6-(Benzyloxycarbonyl-tert-butoxycarbonyl-amino)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester 
• 197891-71-7 6-Benzyloxycarbonylamino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-hex-2E-enoic acid methyl ester 
• 197891-69-3 C₂₀H₂₇NO₇ 
• 214050-58-5 (E)-6-Benzyloxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-hex-2-enoic acid methyl ester 
• 214050-57-4 (E)-6-Benzyloxycarbonylamino-4-hydroxy-hex-2-enoic acid methyl ester 
• 197891-68-2 4-(N-Boc-N-Z-amino)butanal 

Relevant academic research and scientific papers

Dihydroxylation of vinyl sulfones: Stereoselective synthesis of (+)- and (-)-febrifugine and halofuginone

(Chemical Equation Presented) The asymmetric dihydroxylation of amino-functionalized vinyl sulfone 19 has been used for the 3-step preparation of 3-hydroxylpiperidine 24 in 86% enantiomeric excess. This enantiomerically enriched building block was used then to synthesize the naturally occurring antimalarial alkaloid febrifugine 1 and its antiangiogenic analogue, halofuginone 3.

Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

There are described according to the invention compounds of formula (I) (relative stereochemistry indicated), wherein R1, R2, R3 and X are as defined in the specification, together with processes for preparing them, compositions containing them and their use as pharmaceuticals. Compounds of formula (I) are indicated inter alia for the treatment of chronic bronchitis.