197897-11-3

Basic information

• Product Name: 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE
• Synonyms: 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE;1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]imidazo[1,2-b]pyridazinium iodide;1-[((7R)-7-aMino-4-carboxy-3,4-didehydrochephaM-3-yl)Methyl]-1H-iMidazo[1,2-b] pyridazin-4-iuM Iodide;(6R,7R)-7-AMino-3-(iMidazo[1,2-b]pyridazin-1(5H)-ylMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydroiodide;(6R,7R)-7-Amino-3-(imidazo[1,2-b]pyridazin-1(5H)-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-;(6R,7R)-7-Amino-3-(imidazo[1,2-b]pyridazin-1(5H)-ylmethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct
• CAS NO: 197897-11-3
• Molecular Formula: C14H16IN5O3S
• Molecular Weight: 461.27801
• EINECS: 1312995-182-4
• Mol File: 197897-11-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE(197897-11-3)
• EPA Substance Registry System: 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE(197897-11-3)

Safety Data

• Hazardous Substances Data: 197897-11-3(Hazardous Substances Data)

Usage

General Description

The chemical compound 1-[((7R)-7-amino-4-carboxy-3,4-didehydrocepham-3-yl)methyl]-1H-imidazo[1,2-b]pyridazin-4-ium iodide is a cationic antibiotic that has broad-spectrum antibacterial activity. It belongs to the class of cephamycin antibiotics and is derived from cephamycin C. It is commonly used to treat infections caused by bacteria that are resistant to penicillin and other antibiotics. 1-[((7R)-7-AMINO-4-CARBOXY-3,4-DIDEHYDROCEPHAM-3-YL)METHYL]-1H-IMIDAZO[1,2-B]PYRIDAZIN-4-IUM IODIDE works by inhibiting bacterial cell wall synthesis, leading to the disruption of the bacterial cell structure and ultimately causing bacterial death. It is an important therapeutic agent for the treatment of various bacterial infections in clinical settings.

Synthetic route

(Z)-(5-amino-[1,2,4]thiadiazol-3-yl)methoxyiminothioacetic acid S-benzothiazol-2-yl ester (89604-91-1) + 7-amino-3-[(imidazo[1,2-b]pyridazinium-1-yl)methyl]-3-cephem-4-carboxylate hydroiodide (197897-11-3) → cefozopran

Conditions	Yield
With tributyl-amine In tetrahydrofuran; water at 20 - 25℃; for 15h; Large scale reaction;	95%