1979-62-0

Usage

Uses

Used in Flavor and Fragrance Industry:
Ethanone, 1-(4-methoxy-3-methylphenyl)-2-phenylis used as a flavoring agent for its aromatic properties, adding distinctive scents to food products and enhancing the sensory experience of consumers.
Used in Perfumery:
Ethanone, 1-(4-methoxy-3-methylphenyl)-2-phenylis also utilized in the creation of perfumes, where its strong aromatic odor contributes to the development of complex and long-lasting fragrances.
Used in Pharmaceutical Research:
Ethanone, 1-(4-methoxy-3-methylphenyl)-2-phenylhas been studied for its potential pharmacological properties, such as anti-inflammatory and anti-tumor effects, making it a candidate for further research and development in the pharmaceutical industry.
Used in Organic Synthesis:
In the field of organic chemistry, Ethanone, 1-(4-methoxy-3-methylphenyl)-2-phenyl- serves as a valuable intermediate in the synthesis of new chemical entities for scientific research, contributing to the advancement of chemical knowledge and the discovery of novel applications.

Upstream product

• 578-58-5 2-methylmethoxybenzene 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 

Downstream Products

• 113058-69-8 (4-methoxy-3-methyl-bibenzyl-α-yl)-methyl-amine 
• 104450-85-3 1-(4-methoxy-3-methylphenyl)-2-phenylethane-1,2-dione 
• 114508-50-8 4-methoxy-3-methyl-bibenzyl-α-ylamine 
• 807267-74-9 α-amino-3-methyl-bibenzyl-4-ol 
• 104450-83-1 3-(o-Methoxytolyl)-2,4,5-triphenylcyclopentadienone 

Relevant academic research and scientific papers

Synthesis and catalytic reactivity in Friedel–Crafts acylations of monobridged bis(cyclopentadienyl)molybdenum(I) carbonyl complexes

When the monobridged biscyclopentadienes (C5H5)R(C5H5) [R = C(CH3)2 (1), Si(CH3)2 (2), C(CH2)5 (3)] reacted with Mo(CO)6 in refluxing xylene, the corresponding complexes [(η5-C5H4)2R][Mo(CO)3]2 [R = C(CH3)2 (4), Si(CH3)2 (5), C(CH2)5 (6)] were obtained. These complexes were separated by chromatography and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The molecular structures of 4 and 5 were determined by X-ray diffraction analysis. Friedel–Crafts acylation reactions of anisole derivatives with aromatic or aliphatic acyl chlorides catalyzed by complexes 4–6 showed that all of these monobridged bis(cyclopentadienyl)molybdenum carbonyl complexes have catalytic activity.

Syntheses, structures, and catalytic activity in Friedel–Crafts acylations of substituted tetramethylcyclopentadienyl molybdenum carbonyl complexes

Reactions of the substituted tetramethylcyclopentadienes [C5HMe4R] [R?=?tBu, Ph, CH2CH2C(CH3)3] with Mo(CO)3(CH3CN)3 in refluxing xylene gave a series of dinuclear molybdenum carbonyl complexes [(η5-C5Me4R)Mo(CO)3]2 [R?=?tBu (1), Ph (2), CH2CH2C(CH3)3 (3)], [(η5-C5MetBu)Mo(μ-CO)2]2 (4)], and [(η5-C5Me4)tBu]2Mo2O4(μ-O) (5)], respectively. Complexes 1–5 were characterized by elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy. In addition, their crystal structures were determined by X-ray crystal diffraction analysis. The catalytic activities of complexes 1–3 in Friedel–Crafts acylation in the presence of o-chloranil has also been investigated; the reactions were achieved under mild conditions to give the corresponding products in moderate yields.

Aluminum dodecatungstophosphate (AlPW12O40) as a non-hygroscopic Lewis acid catalyst for the efficient Friedel-Crafts acylation of aromatic compounds under solvent-less conditions

Stable and non-hygroscopic aluminum dodecatungstophosphate (AlPW 12O40), which is prepared easily from cheap and commercially available compounds was found to be an effective catalyst for Friedel-Crafts acylation reactions using carboxylic acids, acetic anhydride and benzoyl chloride in the absence of solvent under mild reaction conditions.

Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors

Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO 2NH2)/methylsulfonyl (SO2Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds were obtained from a brief structure-activity relationship (SAR) study. Two of these, compounds 11 and 25 exhibited excellent in vivo activity in the established animal model of inflammation. Since compound 25 possessed an amenable sulfonamide group, two of its prodrugs 48 and 49 were also synthesized. Both of them have excellent in vivo potential, and represent a new class of COX-2 inhibitor.

Synthesis of Some New Polynuclear Compounds by Cycloaddition Reaction

A large number of 7,9-disubstituted derivatives (I) of cyclopentacenaphthylene-8(H)-one and 2,5-disubstituted derivatives (II) of 3,4-diphenylcyclopentadienone have been synthesized by condensing acenaphthaquinone and benzil separately with suitable 1,3-disubstituted propan-2-ones.The 3-(o- and p-methoxytolyl)cyclopentadienones (IX) have been synthesized by Friedel-Crafts reaction of appropriate methyl cresyl ethers and phenacyl chloride.These dienones have been subjected to Diels-Alder reaction with acenaphthylene and a new acetylenic dienophile (V) (whose synthesis is also described in this paper) to yield a large number of polynuclear aromatic compounds having fluoranthene and p-quaterphenyl nuclei, which have been finally characterised by elemental analyses, IR and PMR spectral data.

Synthesis of Some Polyphenylated Aromatic Compounds Using Tetracyclone Derivatives

The 3-(o- and p-methoxytolyl)-2,4,5-triphenylcyclopentadienones (I) have been synthesised and subjected to Diels-Alder reaction with diphenylacetylene and bicyclo-hepta-2,5-diene to give the polyphenylated aromatic hydrocarbons.The products have been characterised by elemental analyses, IR, PMR and UV spectra.