197904-84-0 Usage
Uses
Apricoxib, is an orally active, selective COX-2 inhibitor, used as as an analgesic and anti-inflammatory agent, and also has anticancer potential, since COX-2 inhibition can reduce tumor growth and augment therapy.
Enzyme inhibitor
This oral COX-2 inhibitor (FW = 356.44 g/mol; CAS 162011-90-7), also
named CS-706 and 4-[2- (4-ethoxyphenyl) -4-methyl-1H-pyrrol-1-yl]-
benzene sulfonamide, targets Cyclooxygenase-2, which is over-
expressed in advanced stage non-small-cell lung cancer (NSCLC), possibly
as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2).
That said, a randomized, double-blind, placebo-controlled, multicenter
phase II study found little evidence of efficacy of apricoxib in
combination with either docetaxel or pemetrexed in patients with
biomarker-selected NSCLC. See also Rofecoxib
Check Digit Verification of cas no
The CAS Registry Mumber 197904-84-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,9,0 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 197904-84:
(8*1)+(7*9)+(6*7)+(5*9)+(4*0)+(3*4)+(2*8)+(1*4)=190
190 % 10 = 0
So 197904-84-0 is a valid CAS Registry Number.
197904-84-0Relevant articles and documents
gamma-alkenyl ketone and preparation method thereof
-
, (2020/02/29)
The invention discloses a gamma-alkenyl ketone preparation method, wherein the target product can be obtained at high yield and high regioselectivity by using acetophenone and 1,3-butadiene as raw materials in the presence of an organic solvent, a catalyst, an additive and a ligand. According to the invention, the method has advantages of high atom economy, high regioselectivity, high yield and the like, can achieve the efficient conversion from a cheap basic organic chemical product 1,3-butadiene to high-added-value gamma-alkenyl ketone, and uses the cheap catalyst, so that the reaction conditions are neutral and mild, and the experimental operation is safe and simple; and the synthesized gamma-alkenyl ketone is a useful synthetic intermediate, can be subjected to a series of conversionsto obtain a series of drug molecule precursors or key intermediates, and has wide application prospect.
Use of cyclooxygenase-2 inhibitors for the treatment and prevention of tumors, tumor-related disorders and cachexia
-
, (2008/06/13)
Certain cyclooxygenase-2 inhibitors are useful for the treatment and prevention of tumours and tumour-related disorders and cachexia.
