1979149-35-3Relevant academic research and scientific papers
Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers
Spanò, Virginia,Frasson, Ilaria,Giallombardo, Daniele,Doria, Filippo,Parrino, Barbara,Carbone, Anna,Montalbano, Alessandra,Nadai, Matteo,Diana, Patrizia,Cirrincione, Girolamo,Freccero, Mauro,Richter, Sara N.,Barraja, Paola
, p. 447 - 461 (2016)
A new series of pyrrolo[3′,2′:6,7]cyclohepta[1,2-d]pyrimidin-2-amines, was conveniently prepared using a versatile and high yielding multistep sequence. A good number of derivatives was obtained and the cellular photocytotoxicity was evaluated in?vitro against three different human tumor cell lines with EC50(0.08–4.96?μM) values reaching the nanomolar level. Selected compounds were investigated by laser flash photolysis. The most photocytotoxic derivative, exhibiting a fairly long-lived triplet state (τ ～ 7?μs) and absorbance in the UV–Vis, was tested in the photo-oxidations of 9,10-anthracenedipropionic acid (ADPA) by singlet oxygen. The photosentizing properties are responsible for the compounds’ ability to photoinduce massive cell death with involvement of mitochondria.
4,5,6,9-TETRAHYDROPYRROLO[2',3':3,4]CYCLOHEPTA[1,2-D] ISOXAZOLE, PROCESS FOR THEIR PRODUCTION AND THEIR USES AS ANTITUMOR AGENTS
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Page/Page column 13, (2016/12/07)
The present invention concerns the synthesis of compounds bearing the pyrrolo[2',3':3,4]cyclohepta[1,2-d]isoxazole structure, and their use for the treatment of pathologies having hyperproliferative features included those having neoplastic nature.
