197922-42-2

Basic information

• Product Name: ALX 0600
• Synonyms: ALX 0600;Gattex;Glucagon-like peptide II [2-glycine] (human);Teduglutide
• CAS NO: 197922-42-2
• Molecular Formula: C164H252N44O55S
• Molecular Weight: 3752.08248
• Mol File: 197922-42-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ALX 0600(CAS DataBase Reference)
• NIST Chemistry Reference: ALX 0600(197922-42-2)
• EPA Substance Registry System: ALX 0600(197922-42-2)

Safety Data

• Hazardous Substances Data: 197922-42-2(Hazardous Substances Data)

Usage

Description

Teduglutide was approved in August 2012 by the European Commission and in December 2012 by the US FDA for the treatment of adults with short bowel syndrome (SBS) who are dependent on parenteral nutrition (PN). Teduglutide (also known as ALX-0600) is a GLP-2 analogue in which glycine has been substituted for alanine at position 2 from the N-terminus, thereby conferring resistance to degradation by DPP-4. Teduglutide has similar binding affinity, agonist potency, and agonist efficacy as GLP-2 in assays with the rat GLP-2 receptor. Administration of teduglutide to rats gave a significant increase in small intestine weight and an increase in the height of intestinal villi. Teduglutide was prepared by solid-phase peptide synthesis.

Originator

NPS Allelix (Canada)

Uses

Treatment of intestinal diseases characterized by chemical or surgical damage of the intestinal epithelium such as Short Bowel Syndrome (SBS) or damage to the intestinal epithelium due to disease (glucagon-like peptide-2 (GLP- 2) analog).

Definition

ChEBI: A 33-membered polypeptide consisting of His, Gly, Asp, Gly, Ser, Phe, Ser, Asp, Glu, Met, Asn, Thr, Ile, Leu, Asp, Asn, Leu, Ala, Ala, Arg, Asp, Phe, Ile, Asn, Trp, Leu, Ile, Gln, Thr, Lys, Ile, Thr and Asp residues joined in sequence. A glucagon-like pep ide-2 receptor agonist used for the treatment of short-bowel syndrome.

Brand name

Gattex

Clinical Use

Human glucagon-like peptide-2 (GLP-2): Treatment of short bowel syndrome

Drug interactions

Potentially hazardous interactions with other drugs Potential for increased absorption of some medications. Monitor narrow therapeutic index drugs carefully.

Metabolism

The metabolism of teduglutide is not fully known. Since teduglutide is a peptide it is likely that it follows the principal mechanism for peptide metabolism. See 'Other information'.