197959-73-2Relevant academic research and scientific papers
AMIDINOHYDRAZONES AS PROTEASE INHIBITORS
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Page/Page column 25-26, (2010/11/23)
Amidino and benzamidino compounds, including compounds of the formula: I wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.
Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors
Linusson,Gottfries,Olsson,?rnskov,Folestad,Nordén,Wold
, p. 3424 - 3439 (2007/10/03)
A library of thrombin inhibitors has been designed using statistical molecular design. An aromatic scaffold was used, with three varied positions corresponding to three pockets at the active site of thrombin (the S-, P-, and D-pockets). The selection was
AMIDINOHYDRAZONES AS PROTEASE INHIBITORS
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, (2008/06/13)
Amidino and benzamidino compounds, including compounds of the formula: STR1 wherein R 1-R 4, R 6-R 9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.
