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197979-50-3

methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride

    Cas No: 197979-50-3

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  • 197979-50-3 Structure

  • Basic information

    1. Product Name: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride
    2. Synonyms:
    3. CAS NO:197979-50-3
    4. Molecular Formula:
    5. Molecular Weight: 494.975
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 197979-50-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride(197979-50-3)
    11. EPA Substance Registry System: methyl (Z)-3-(3',5'-dimethoxyphenyl)-2-[(E)-2-phenyl-1-(pyridin-3-ylcarbamoyl)vinyl]-2-butenoate hydrochloride(197979-50-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 197979-50-3(Hazardous Substances Data)

197979-50-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 197979-50-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,7,9,7 and 9 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 197979-50:
(8*1)+(7*9)+(6*7)+(5*9)+(4*7)+(3*9)+(2*5)+(1*0)=223
223 % 10 = 3
So 197979-50-3 is a valid CAS Registry Number.

197979-50-3Downstream Products

197979-50-3Relevant articles and documents

Synthesis and evaluation of 1,4-diphenylbutadiene derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Miyazaki, Hiroshi,Sai, Hiroshi,Ohmizu, Hiroshi,Murakami, Jun,Ohtani, Akio,Ogiku, Tsuyoshi

, p. 1968 - 1979 (2010)

Butadiene-imide 1 (T-686) derivatives were synthesized and evaluated for their inhibitory activity against PAI-1 production and their ADMET (DMPK and toxicology) profiles. Among these derivatives, compound 15k (T-2639) showed good antithrombotic activity in two rat thrombosis models without affecting bleeding time, indicating reduction of haemorrhagic risk. We also describe in this report a practical synthesis of 15k suitable for scale-up using Z,E-selective Stobbe condensation.

Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production

Miyazaki, Hiroshi,Ogiku, Tsuyoshi,Sai, Hiroshi,Ohmizu, Hiroshi,Murakami, Jun,Ohtani, Akio

scheme or table, p. 6419 - 6422 (2009/09/06)

A novel series of butadiene-imide 1 (T-686) derivatives having an inhibitory activity against PAI-1 production was synthesized and evaluated their biological activities and DMPK profiles, in which 15k (T-2639) was selected as the best compound based on its strong antithrombotic activity and good bioavailability.

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