1980040-52-5

Basic information

• Product Name: Meptazinol iMpurity E
• Synonyms: Meptazinol iMpurity E
• CAS NO: 1980040-52-5
• Molecular Formula: C19H31NO
• Molecular Weight: 289.46
• Mol File: 1980040-52-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Meptazinol iMpurity E(CAS DataBase Reference)
• NIST Chemistry Reference: Meptazinol iMpurity E(1980040-52-5)
• EPA Substance Registry System: Meptazinol iMpurity E(1980040-52-5)

Safety Data

• Hazardous Substances Data: 1980040-52-5(Hazardous Substances Data)

Upstream product

• 71556-72-4 3-Ethyl-hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one 
• 71592-43-3 hexahydro-3-(3-methoxyphenyl)-1-methyl-2H-azepin-2-one 
• 2556-73-2 1-methyl-2-azepanone 
• 766-51-8 2-Chloroanisole 

Relevant articles and documents

Method for preparing MPTF-E (meptazinol E)

The invention discloses a method for preparing MPTF-E (meptazinol E), and belongs to the technical field of chemical drug preparation. The method comprises the following steps: (1) chloroanisole reacts with N-methylcaprolactam, and a compound I is obtained; (2) the compound I reacts with iodoethane, and a compound II is obtained; (3) boron bromide reacts with the compound II, and a compound III is obtained; (4) the compound III reacts with bromobutane, and a compound IV is obtained; (5) the compound IV is dissolved in anhydrous THF (tetrahydrofuran), lithium aluminum hydride is added, reaction reflux is performed, reactants are cooled to the room temperature, H2O is slowly added to a reaction liquid, then MgSO4 is added for stirring, filtration, reduced-pressure distillation and purification are performed, and a compound V is obtained. The method has the following advantages that MPTF-E is synthesized for the first time, and qualified impurity E comparison products are provided for meptazinol; a reagent adopted is a common solvent and easy to obtain; safe solvents such as ethyl acetate, petroleum ether and the like are used for treatment and have low toxicity; the process is simple and easy to operate, little energy is consumed, the stability is high, and the purity is high.