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198022-70-7

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198022-70-7 Usage

Description

AM-404 (198022-70-7) inhibits anandamide transport (IC50?= 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2?Vanilloid receptors are activated by AM-404.3?Active?in vivo.1

Biological Activity

Competitive and selective inhibitor of carrier-mediated anandamide transport (IC 50 = 1 μ M). Does not activate CB 1 receptors or inhibit anandamide hydrolysis but has been shown to activate native and cloned vanilloid receptors (pEC 50 = 7.4). Active in vivo . Also available in water soluble emulsion (N-(4-Hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).

References

1) Calignano?et al. (1997),?Potentiation of anandamide hypotension by the transport inhibitor AM404; Eur. J. Pharmacol.,?337?R1 2) Beltramo?et al. (1997), Functional role of high-affinity anandamide transport, as revealed by selective inhibition; Science,?277?1094 3) Zygmunt?et al. (2000),?The anandamide inhibitor AM404 activates vanilloid receptors: Eur. J. Pharmacol.?396?39

Check Digit Verification of cas no

The CAS Registry Mumber 198022-70-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,0,2 and 2 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 198022-70:
(8*1)+(7*9)+(6*8)+(5*0)+(4*2)+(3*2)+(2*7)+(1*0)=147
147 % 10 = 7
So 198022-70-7 is a valid CAS Registry Number.

198022-70-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-arachidonoylaminophenol

1.2 Other means of identification

Product number -
Other names AM404

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:198022-70-7 SDS

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