198056-28-9

Basic information

• Product Name: 3-[2-(1-Piperidinyl)ethyl]-6-propylbenzothiazol-2(3H)-one
• CAS NO: 198056-28-9
• Molecular Formula: C₁₇H₂₄N₂OS
• Molecular Weight: 304.45763
• Mol File: 198056-28-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[2-(1-Piperidinyl)ethyl]-6-propylbenzothiazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(1-Piperidinyl)ethyl]-6-propylbenzothiazol-2(3H)-one(198056-28-9)
• EPA Substance Registry System: 3-[2-(1-Piperidinyl)ethyl]-6-propylbenzothiazol-2(3H)-one(198056-28-9)

Safety Data

• Hazardous Substances Data: 198056-28-9(Hazardous Substances Data)

Upstream product

• 115444-23-0 3-propionylbenzo[d]thiazol-2(3H)-one 
• 133044-35-6 6-propionylbenzo[d]thiazol-2(3H)-one 
• 934-34-9 2(3H)-Benzothiazolone 
• 198056-33-6 3-(2-Piperidin-1-yl-ethyl)-6-propionyl-3H-benzothiazol-2-one 

Relevant articles and documents

Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)- benzothiazolone derivatives

A series of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives were synthesized and evaluated for anticonvulsant activity. The compounds were assayed, intraperitoneally in mice and per os in rats, against seizures induced by maximal electroshock (MES) and pentylene-tetrazole (scMet). Neurologic deficity was evaluated by the rotarod test. The compounds were prepared to determine the relationship between the 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives' structures and anticonvulsant activity. Several of these compounds showed significant anticonvulsant activity. Compounds 43 and 45 were the most active of the series against MES-induced seizures with ED50 values of 8.7 and 7.6 mg/kg, respectively. Compound 45 displayed good protection against MES-induced seizures and low toxicity in rats with an oral ED50 of 18.6 mg/kg and a protective index (PI = TD50/ED50) of 1 receptors with nanomolar affinities.