198135-26-1Relevant articles and documents
A facile synthesis of pyrazole, isoxazole and pyrimidine ortho-dicarboxylic acid derivatives via β-enaminoketoesters
Veronese, Augusto C.,Callegari, Rosella,Morelli, Carlo F.,Vicentini, Chiara B.
, p. 14497 - 14506 (1997)
β-Alkoxycarbonyl-β-enaminoketoesters 1a,b react with hydrazines to give pyrazole orthodicarboxylic acid derivatives 3, 4 and 5. Similarly la reacts with hydroxylamine to give isoxazole 6 and with amidines and guanidine to give pyrimidine ortho-dicarboxylic acid monoesters 7a-c. The total or partial hydrolysis of selected heterocycles afforded the dicarboxylic acids 8, 9 and 10 and the dicarboxylic acid monoesters 11 and 12.
