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198206-33-6

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198206-33-6 Usage

General Description

3-(Trifluoromethoxy)iodobenzene is a chemical compound with the molecular formula C7H4F3IO. It is a substituted phenyl compound containing a trifluoromethoxy group and an iodine atom. 3-(Trifluoromethoxy)iodobenzene is used as a reagent in organic synthesis, particularly in the preparation of aromatic iodides and fluorides. It is also used in the pharmaceutical industry as a building block for the synthesis of potential drug candidates. 3-(Trifluoromethoxy)iodobenzene is a versatile reagent with applications in medicinal chemistry, agrochemicals, and material science. Its ability to introduce fluorine and iodine atoms into organic molecules makes it a useful tool in the design and synthesis of new compounds for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 198206-33-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,2,0 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 198206-33:
(8*1)+(7*9)+(6*8)+(5*2)+(4*0)+(3*6)+(2*3)+(1*3)=156
156 % 10 = 6
So 198206-33-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F3IO/c8-7(9,10)12-6-3-1-2-5(11)4-6/h1-4H

198206-33-6 Well-known Company Product Price

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  • TCI America

  • (I0813)  1-Iodo-3-(trifluoromethoxy)benzene  >98.0%(GC)

  • 198206-33-6

  • 5g

  • 790.00CNY

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  • Alfa Aesar

  • (B24169)  1-Iodo-3-(trifluoromethoxy)benzene, 97+%   

  • 198206-33-6

  • 1g

  • 321.0CNY

  • Detail
  • Alfa Aesar

  • (B24169)  1-Iodo-3-(trifluoromethoxy)benzene, 97+%   

  • 198206-33-6

  • 5g

  • 1254.0CNY

  • Detail

198206-33-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-iodo-3-(trifluoromethoxy)benzene

1.2 Other means of identification

Product number -
Other names 1-Iodo-3-(trifluoroMethoxy)benzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:198206-33-6 SDS

198206-33-6Relevant articles and documents

Radical C?H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide

Dix, Stefan,Golz, Paul,Schmid, Jonas R.,Riedel, Sebastian,Hopkinson, Matthew N.

supporting information, p. 11554 - 11558 (2021/07/09)

Trifluoromethoxylated (hetero)arenes are of great interest for several disciplines, especially in agro- and medicinal chemistry. Radical C?H trifluoromethoxylation of (hetero)arenes represents an attractive approach to prepare such compounds, but the high cost and low atom economy of existing .OCF3 radical sources make them unsuitable for the large-scale synthesis of trifluoromethoxylated building blocks. Herein, we introduce bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent that is easily accessible from inexpensive bulk chemicals. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics. Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which have been previously prepared via multi-step approaches.

Radical Trifluoromethoxylation of Arenes Triggered by a Visible-Light-Mediated N?O Bond Redox Fragmentation

Jelier, Benson J.,Tripet, Pascal F.,Pietrasiak, Ewa,Franzoni, Ivan,Jeschke, Gunnar,Togni, Antonio

supporting information, p. 13784 - 13789 (2018/09/14)

A simple trifluoromethoxylation method enables non-directed functionalization of C?H bonds on a range of substrates, providing access to aryl trifluoromethyl ethers. This light-driven process is distinctly different from conventional procedures and occurs through an OCF3 radical mechanism mediated by a photoredox catalyst, which triggers an N?O bond fragmentation. The pyridinium-based trifluoromethoxylation reagent is bench-stable and provides access to synthetic diversity in lead compounds in an operationally simple manner.

2-, 3-, and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds

Castagnetti, Eva,Schlosser, Manfred

, p. 691 - 695 (2007/10/03)

Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3- and 4-isomers can readily be generated from the corresponding 3- and 4-bromo precursors by halogen-metal interconversion with butyllithium or tertbutyllithium. Upon trapping of the 2-, 3- and 4-(trifluoromethoxy)phenyllithiums with 11 different electrophiles the expected products were formed in generally high yields. Only the attempted nucleophilic addition of 2-(trifluoromethoxy)phenyllithium to oxirane did not succeed. This failure is tentatively attributed to a lowering of the nucleophilicity by fluorine-lithium interactions. Conformationally restricted analogs - i.e., 2,2-difluoro-1,3-benzodioxol-4-phenyllithium and its 5-fluoro- and 5-bromo-substituted congeners - did indeed react smoothly with oxirane, affording the adducts in ordinary yields.

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