198208-51-4

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octan-2-one,3-fluoro-8-methyl-,(1S,3R,5R)-(9CI)
• Synonyms: 8-Azabicyclo[3.2.1]octan-2-one,3-fluoro-8-methyl-,(1S,3R,5R)-(9CI)
• CAS NO: 198208-51-4
• Molecular Formula: C8H12FNO
• Molecular Weight: 157.19
• Product Categories: PYRROLE;HALIDE
• Mol File: 198208-51-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octan-2-one,3-fluoro-8-methyl-,(1S,3R,5R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octan-2-one,3-fluoro-8-methyl-,(1S,3R,5R)-(9CI)(198208-51-4)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octan-2-one,3-fluoro-8-methyl-,(1S,3R,5R)-(9CI)(198208-51-4)

Safety Data

• Hazardous Substances Data: 198208-51-4(Hazardous Substances Data)

Upstream product

• 91645-70-4 5-(2-ethoxycarbonyl-ethyl)-pyrrole-2-carboxylic acid ethyl ester 
• 93647-41-7 2-ethoxycarbonyl-5-(2'-ethoxycarbonylethyl)-1-methylpyrrolidine 
• 91691-27-9 ethyl 5-(3-ethoxy-3-oxopropyl)pyrrolidine-2-carboxylate 
• 91340-84-0 3-ethoxycarbonyl-8-methyl-8-azabicyclo[3.2.1]octan-2-one 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 7126-50-3 ethyl 5-formyl-1H-pyrrole-2-carboxylate 
• 436159-80-7 ethyl (E)-5-(3-ethoxy-3-oxoprop-1-en-1-yl)-1H-pyrrole-2-carboxylate 
• 198208-49-0 3-ethoxycarbonyl-3-fluoro-8-methyl-8-azabicyclo[3.2.1]octan-2-one 

Relevant articles and documents

Chiral fluoro ketones for catalytic asymmetric epoxidation of alkenes with oxone

Two structurally dissimilar, chiral fluoro ketones have been prepared and their potential as enantioselective catalysts for asymmetric epoxidation with Oxone has been evaluated. The tropinone-based ketone (-)-5 was easily prepared and showed excellent reactivity but only modest enantioselectivity. The biphenyl-based ketone (-)-6 was prepared in a somewhat lengthy synthesis (along with its monofluoro and geminal fluoro analogues). This ketone exhibited only modest reactivity; 30 mol % of (-)-6 was needed to bring about complete conversion in a reasonable time. The enantioselectivity of this catalyst was generally much higher, but again very substrate dependent.