198211-41-5Relevant academic research and scientific papers
Preparation and application of deubiquitinating enzyme inhibitor
-
Paragraph 0107-0110, (2021/06/06)
The invention aims to provide a compound with single/double inhibitory activity on USP25 and USP28 proteases. The invention provides a compound shown as a formula I and a racemate, a stereoisomer, an isotope label, nitrogen oxide, a solvate, a polymorphic substance, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound.
Ubiquitination specific protease inhibitor and preparation method and application thereof
-
Paragraph 0138-0142, (2020/11/22)
The present invention relates to a compound represented by a formula I, a racemate, a stereoisomer, a tautomer, an isotope marker, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof, a pharmaceutical composition containing the compound, a preparation method and a medical use of the compound, wherein the compound has USP28 and/or USP25 inhibition activity, and the structure of the formula I is shown in the specification.
6-phenyl-pyridin-2-ylamine derivatives
-
, (2008/06/13)
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders.
