198220-11-0Relevant articles and documents
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4)
Williams, Richard,Johnson, Kari A.,Gentry, Patrick R.,Niswender, Colleen M.,Weaver, Charles D.,Conn, P. Jeffrey,Lindsley, Craig W.,Hopkins, Corey R.
scheme or table, p. 4967 - 4970 (2010/03/24)
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
