198220-35-8Relevant articles and documents
Dimethylamine substitution in N,N-dimethyl enamines. Synthesis of aplysinopsin analogues and 3-aminotetrahydrocoumarin derivatives
Seli?, Lovro,Stanovnik, Branko
, p. 3159 - 3164 (2001)
Some new six-membered aplysinopsin analogues were prepared from 5-dimethylaminomethylidene-2,4,6(1H,3H,5H)-pyrimidinetriones and indole derivatives. Also 2-[[(2,4,6-trioxohexahydropyrimidin-5-ylidene)methyl]amino]-3- dimethylaminopropenoates were synthesized and employed in the synthesis of fused 2H-pyran-2-ones.
Design, synthesis and anticancer activities of hybrids of indole and barbituric acids-Identification of highly promising leads
Singh, Palwinder,Kaur, Matinder,Verma, Pooja
scheme or table, p. 3054 - 3058 (2010/02/28)
By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Evaluations of these molecules over 60 cell line panel of human cancer cells have identified two molecules with significant anticancer activities. Dockings of two active molecules in the active sites of COX-2, thymidylate synthase and ribonucleotide reductase indicate their strong interactions with these enzymes.