198226-90-3

Basic information

• Product Name: 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-(diphenylphosphoryl)-D-mannitol
• Synonyms: 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-(diphenylphosphoryl)-D-mannitol
• CAS NO: 198226-90-3
• Molecular Weight: 773.708
• Mol File: 198226-90-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-(diphenylphosphoryl)-D-mannitol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-(diphenylphosphoryl)-D-mannitol(198226-90-3)
• EPA Substance Registry System: 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-(diphenylphosphoryl)-D-mannitol(198226-90-3)

Safety Data

• Hazardous Substances Data: 198226-90-3(Hazardous Substances Data)

Upstream product

• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 259811-49-9 [[(4R,5R)-5-((1R,2R)-1,2-Diacetoxy-3-hydroxy-propyl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl]-(diethoxy-phosphorylmethyl)-amino]-acetic acid ethyl ester 
• 40036-82-6 [2,3:5,6]-di-O-isopropylidene-D-mannose 
• 198226-89-0 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3-O-isopropylidene-4,5-di-O-acetate-6-[(tert-butyl)dimethylsilyl]-D-mannitol 
• 198226-88-9 1-deoxy-1-[(diethylphosphonomethyl)(2-ethoxy-2-oxoethyl)amino]-2,3:5,6-di-O-isopropylidene-D-mannitol 
• 259811-48-8 {(Diethoxy-phosphorylmethyl)-[(4R,5S)-2,2-dimethyl-5-((1R,2R)-1,2,3-trihydroxy-propyl)-[1,3]dioxolan-4-ylmethyl]-amino}-acetic acid ethyl ester 
• 198226-87-8 1-deoxy-1-[(2-ethoxy-2-oxoethyl)amino]-2,3:5,6-di-O-isopropylidene-D-mannitol 
• 106938-62-9 (diethoxyphosphinyl)methyl trifluoromethanesulfonate 

Relevant articles and documents

Towards the development of novel antibiotics: Synthesis and evaluation of a mechanism-based inhibitor of Kdo8P synthase

The design and two synthetic pathways to aminophosphonate 4 which mimics the ionic and steric properties of putative oxocarbenium intermediate 3 in the Kdo8P synthase-catalyzed reaction are reported. It was found that 4 is a slow-binding, most potent inhibitor of the enzyme yet tested, with a K(i) value of 0.4 μM. Copyright (C) 1999 Elsevier Science Ltd.