198283-74-8

Basic information

• Product Name: 5-[(2R)-azetidin-2-ylmethoxy]-2-chloropyridine 4-methylbenzenesulfonate
• Synonyms: 5-[(2R)-Azetidin-2-ylmethoxy]-2-chloropyridine 4-methylbenzenesulfonate (1:1); pyridine, 5-[(2R)-2-azetidinylmethoxy]-2-chloro-, 4-methylbenzenesulfonate (1:1)
• CAS NO: 198283-74-8
• Molecular Formula: C₁₆H₁₉ClN₂O₄S
• Molecular Weight: 370.8511
• Mol File: 198283-74-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 321.1°C at 760 mmHg
• Flash Point: 148°C
• Vapor Pressure: 0.000305mmHg at 25°C
• CAS DataBase Reference: 5-[(2R)-azetidin-2-ylmethoxy]-2-chloropyridine 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(2R)-azetidin-2-ylmethoxy]-2-chloropyridine 4-methylbenzenesulfonate(198283-74-8)
• EPA Substance Registry System: 5-[(2R)-azetidin-2-ylmethoxy]-2-chloropyridine 4-methylbenzenesulfonate(198283-74-8)

Safety Data

• Hazardous Substances Data: 198283-74-8(Hazardous Substances Data)

Upstream product

• 188057-24-1 5-Acetoxy-2-chloropyridine 
• 41288-96-4 6-chloropyridine-3-ol 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 104-15-4 toluene-4-sulfonic acid 
• 209328-50-7 2-chloro-5-((1-(tert-butoxycarbonyl))-2-(R)-azetidinylmethoxy)pyridine 

Relevant articles and documents

Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic

A concise asymmetric synthesis of (R)-2-chloro-5-(2- azetidinylmethoxy)pyridine (ABT-594) is presented in which the key intermediate t-butoxycarbonyl protected (2R)-azetidinylalcohol is obtained in three steps from the dibenzyl ester of D-aspartic acid in 44% yield and >99% ee.