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Usage

Uses

Used in Pharmaceutical Applications:
GAP 27 is used as a therapeutic agent for improving cell migration during scrape-wound repair, particularly in conditions characterized by hyperglycemia and hyperinsulinemia. Its ability to inhibit connexin-mediated communication aids in the healing process and promotes tissue regeneration.
Used in Smooth Muscle Cell Applications:
In the context of smooth muscle cells, GAP 27 is used as a modulator to reduce acetylcholine-induced hyperpolarization. This application can be beneficial in managing conditions related to smooth muscle cell function and signal transmission.
Overall, GAP 27 is a versatile compound with potential applications in various industries, including pharmaceuticals and cell biology, due to its ability to modulate cellular processes and improve cell function under specific conditions.

Biological Activity

gap 27 is a peptide(ser-arg-pro-thr-glu-lys-thr-ile-phe-ile-ile) derived from connexin 43 that is a selective gap junction blocker.connexins, or gap junctions, are a family of structurally-related transmembrane proteins. gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. this intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. this synthetic connexin-mimetic peptide, gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. it was concluded that gap-junctional communication is necessary for proper bone remodeling.figure1 formula of gap 27

references

1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).