198334-38-2 Usage
Uses
Used in Pharmaceutical Industry:
4-thien-2-ylpiperidine is used as a reactant for the preparation of pyrido-pyrimidinones, which are histone lysine demethylase inhibitors. These inhibitors have potential antitumor properties, making them valuable in the development of new cancer treatments.
In the context of cancer research and drug development, 4-thien-2-ylpiperidine plays a crucial role in the synthesis of compounds that can modulate the activity of histone lysine demethylases. These enzymes are involved in the regulation of gene expression and have been implicated in the development and progression of various types of cancer. By inhibiting the activity of these enzymes, pyrido-pyrimidinones derived from 4-thien-2-ylpiperidine may help to restore normal gene expression patterns and inhibit tumor growth.
Furthermore, the use of 4-thien-2-ylpiperidine in the pharmaceutical industry extends beyond its application as a reactant for histone lysine demethylase inhibitors. Its unique chemical properties and structural features make it a promising candidate for the development of other therapeutic agents targeting a wide range of diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 198334-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,8,3,3 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 198334-38:
(8*1)+(7*9)+(6*8)+(5*3)+(4*3)+(3*4)+(2*3)+(1*8)=172
172 % 10 = 2
So 198334-38-2 is a valid CAS Registry Number.
198334-38-2Relevant articles and documents
PIPERIDINE DERIVATIVE
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Page/Page column 47-48, (2010/11/25)
For example, a piperidine derivative represented by following formula (I) (wherein, -C(=O)-Z- represents -C(=O)-CH 2 -, -C(=O)-C(CH 3 ) 2 -, -C(=O)-NH-, -C(=O)-O-, -C(=O)-S-, - C(=O)-CH 2 CH 2 -, -C(=O)-CH=CH-, -C(=O)-CH 2 O-, -C(=O)-CH 2 S-, - C(=O)-CH 2 CH 2 CH 2 - or -C(=O)-NR 8 CH 2 -; R 1 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R 2 represents a hydrogen atom or hydroxy; R 3 represents a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R 5 represents a hydrogen atom, hydroxy, or the like; R 6 represents a hydrogen atom, hydroxy, substituted or unsubstituted lower alkyl, or the like, etc.; R 7 represents a hydrogen atom, halogen, substituted or unsubstituted lower alkyl, or the like; n and k each independently represents an integer of 0 to 2; and represents a single bond, or a double bond together with R 4 , where in case is a single bond, R 4 represents a hydrogen atom, hydroxy, or the like) or a pharmaceutically acceptable salt thereof and the like having an antagonistic activity for a glutamic acid receptor (NR2B/NMDA receptor) of an N-methyl-D-aspartic acid (NMDA) type containing an NR2B subunit are provided.
