198348-90-2

Upstream product

• 4027-54-7 3-(trifluoromethyl)-5-phenylpyrazole 
• 4027-54-7 3-phenyl-5-(trifluoromethyl)-1H-pyrazole 
• 326-06-7 1-Phenyl-4,4,4-trifluorobutane-1,3-dione 

Relevant academic research and scientific papers

3-Trifluoromethyl-4-nitro-5-arylpyrazoles are novel KATP channel agonists

This communication describes the discovery and synthesis of a series of 3-trifluoromethyl-4-nitro-5-arylpyrazoles as potent KATP channel agonists. The most potent compound reported is ca. 100-fold more potent than diazoxide and exhibits selectivity for the SUR1 KATP channel subtype. The 4-nitro substitutent on the pyrazole ring was required for activity, and limited SAR suggests that the de-protonated pyrazole maybe the active species.

Nitropyrazoles: 10. N-nitration of 3(5)-substituted pyrazoles

A number of substituted N-nitropyrazoles were prepared by direct nitration of substituted pyrazoles. The dependence of the direction of nitration on the reaction conditions was studied.