1984-43-6

Basic information

• Product Name: dimethyl (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate
• Synonyms: 7-Oxabicyclo(2.2.1)hept-5-ene-2,3-dicarboxylic acid, dimethyl ester, (exo,exo)-
• CAS NO: 1984-43-6
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.1993
• Mol File: 1984-43-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 288.9°C at 760 mmHg
• Flash Point: 124.9°C
• Density: 1.287g/cm³
• Vapor Pressure: 0.00227mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: dimethyl (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate(1984-43-6)
• EPA Substance Registry System: dimethyl (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate(1984-43-6)

Safety Data

• Hazardous Substances Data: 1984-43-6(Hazardous Substances Data)

Upstream product

• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 
• 77-78-1 dimethyl sulfate 
• 5426-09-5 4,10-dioxatricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione 
• 101752-05-0 methanol hydrochloride 
• 67-56-1 methanol 

Downstream Products

• 110-00-9 furan 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 23200-40-0 5exo,6exo-dibromo-7-oxa-norbornane-2exo,3exo-dicarboxylic acid dimethyl ester 
• 19686-53-4 (+/-)-5endo,6exo-dibromo-7-oxa-norbornane-2exo,3exo-dicarboxylic acid dimethyl ester 
• 728-47-2 Dimethyl 4-(trifluoromethyl)phthalate 
• 5785-54-6 (+/-)-(7ar)-3,3a,4,5,6,7a-Hexahydro-4t,7t-epoxido-2H-indazol-5t,6t-dicarbonsaeure-dimethylester 
• 55423-53-5 (2-endo,3-exo)-7-oxabicyclo<2.2.1>heptane-2,3-dimethanol 
• 129814-71-7 dimethyl (1RS,2SR,4RS,5SR,6RS,7RS)-3-benzoyl-8-oxa-3-azatricyclo<3.2.1.0^2,4>octane-6,7-dicarboxylate 
• 129814-71-7 dimethyl (1RS,2SR,4RS,5SR,6SR,7RS)-3-benzoyl-8-oxa-3-azatricyclo<3.2.1.0^2,4>octane-6,7-dicarboxylate 
• 129814-65-9 dipropyl (1RS,2SR,6SR,7SR,8SR,9SR)-4-phenyl-3,10-dioxa-5-azatricyclo<5.2.1.0^2,6>dec-4-ene-8,9-dicarboxylate 

Relevant articles and documents

Synthesis and crystal structure of dimethyl-7-oxabicyclo[2.2.1]hept-5-ene exo,exo-2,3-dicarboxylate

Dimethyl-7-oxabicyclo[2.2.1]hept-5-ene exo,exo-2,3-dicarboxylate (1) was prepared by Fisher esterification of 7-oxabicyclo[2.2.1]-hept-5-ene exo-2,3-dicarboxylic anhydride (2) in methanol. The colorless plates obtained were characterized by FT-IR, 1H- and 13C-NMR, TGA-DSC, and single crystal X-ray diffraction. The material crystallizes in space group P21/c, with a = 9.2375(14) A, b = 12.8757(18) A, c = 9.4608(15) A, β = 115.327(3)°, V = 1017.1(3) A3, and Z = 4. Chains of hydrogen-bonded molecules along the c-axis interact in the b direction to form layers parallel to the bc plane.

Cyclohexanedicarboxylic acid derivative with bridge ring and pharmaceutical composition and application thereof

The invention discloses a cyclohexane dicarboxylic acid derivative with a bridged ring represented by general formula (I). The application of the stereoisomers and the pharmaceutically acceptable salts in the preparation of antitumor drugs has obvious inhibition effects on leukemia, liver cancer, lung cancer, gastric cancer and ovarian cancer. The compound disclosed by the invention has high anti-tumor activity, wide anti-tumor spectrum and low toxicity, and is suitable for preparing anti-cancer drugs.

Palladium-Catalyzed [2+1] Cycloadditions Affording Vinylidenecyclopropanes as Precursors of 7-Membered Carbocycles

Palladium(II) acetate in association with secondary phosphine oxides provides an efficient catalytic system for [2+1] cycloadditions starting from oxanorbornene derivatives and tertiary propargyl esters giving rise to vinylidenecyclopropanes. This reaction is specific to bidentate phosphinito-phosphinous acid ligands generated from secondary phosphine oxides. The [2+1] cycloaddition was found broad in scope with a high tolerance to various functional groups. Moreover, vinylidenecyclopropanes were straightforwardly converted into oxabicyclo[3.2.1]oct-2-ene derivatives through a palladium-catalyzed ring-expansion. Finally, the oxa bridge cleavage of oxatricyclic compounds yields functionalized 7-membered carbocycles.