19841-84-0Relevant articles and documents
An efficient synthesis and mechanism of formation of 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid
Sanchez, Joseph P.
, p. 7693 - 7698 (1990)
Starting with 3,3-dimethoxy-2-butanone (biacetyl monoketal) (1), 6-acetyl-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid (9a) has been prepared in large quantities by a highly efficient synthetic sequence. The isolation of 2-cyano-5-hydroxy-6-oxo-2,4-heptadienamide (6) and the identification of 2-cyano-6,6-dimethoxy-5-oxo-2-heptenamide (4a) from the reaction mixture suggests that the final ring closure may involve a dehydration of this sterically hindered enamide.