198418-05-2

Upstream product

• 622-30-0 N-benzyl hydroxylalmine 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 198418-04-1 (3R,4S)-3-(acetoxyamino)-N-benzyl-4,5-dihydroxy-4,5-O-isopropylidene-1-pentyne 
• 186581-53-3 diazomethane 
• 181303-69-5 N-Benzyl-N-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-trimethylsilanyl-prop-2-ynyl]-hydroxylamine 
• 198418-03-0 N-Benzyl-N-[(R)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-prop-2-ynyl]-hydroxylamine 
• 91190-38-4 N-benzyl-2,3-O-isopropylidene-D-glyceraldehyde nitrone 

Relevant academic research and scientific papers

Diastereoselective nucleophilic addition of acetylide to N-benzyl-2, 3- O-isopropylidene-D-glyceraldehyde nitrone (BIGN). Stereodivergent synthesis of β-hydroxy-α-(hydroxyamino)- and βhydroxy-α-amino acids

The stereocontrolled nucleophilic addition of lithium trimethylsilyl acetylide to the N-benzyl nitrone (BIGN) derived from 2,3-O-isopropylidene- D-glyceraldehyde, followed by oxidative cleavage of the ensuing propargyl hydroxylamines resulted in an efficient stereodivergent synthesis of fully protected epimeric N. hydroxy α-amino esters 8 and 13 as well as the corresponding α-amino esters 9 and 14.